Lysine methyl ester

Agarwal et used glycerol in combination with PEO, lysine methyl ester dusocyanate... 

Fig. 16 Manipulation of deprotected C-glucopyranosides. Reagents and conditions (a) i. BTSFA, CH3CN, reflux ii. allyltrimethylsilane, TMSOTf, 0 °C-room temp., 12 h (b) NIS, HzO, 2 h (c) Bu4NN3, H20, 80 °C, 72 h (d) Cs2C03, Cys-NAc-OMe, MeOH-DMF 2 1 (e) hv, W-acetyl L-cvsteine methyl ester, MeOH/H20 (f) i. 03, ii. Me2S (g) W-acetyl L-lysine methyl ester, MeOH, AcOH, NaBH3CN.

Figure 16. Morphology of measured crystals of (S)-lysine-HC1 2H20 viewed along the a and c axes (a) pure (b),(c) grown in the presence of (b) (S)-lysine methyl ester, (c) (S)-norleucine.

To further exploit the potential usefiilness of this new family of clusters, monoadduct 54 was saponified into 55 (0.05 M NaOH, quant) and condensed to L-lysine methyl ester using 2-ethoxy-l-ethoxycarbonyl-l,2-dihydroquinoline (EEDQ) to give extended dimer 56 in 50 % yield together with monoadduct in 15 % yield [75]. Additionally, tert-butyl thioethers 52 could be transformed into thiols by a two step process involving 2-nitrobenzenesulfenyl chloride (2-N02-PhSCl, HOAc, r.t, 3h, 84%) followed by disulfide reduction with 2-mercaptoethanol (60%). Curiously, attempts to directly obtain these thiolated telomers by reaction with thioacetic acid f ed. These telomers were slightly better ligands then lactose in inhibition of binding of peanut lectin to a polymeric lactoside [76]. 

Guelcher et al. (1) prepared a hydrolyzable polyurethane foam under physiological conditions by condensing a polyester triol with e-caprolactone/glycolide and then postreacting the intermediate ester with the biocompatible diocyanate, lysine methyl ester diisocyanate. 

Ar-(4-Benzoylbenzoyl)-Aa-(fcrf-butoxycarbonyl)lysine Methyl Ester (85) [152)... 

Diphenylphosphino)benzoyl)-M-a-(6-(2-(2-sulfonatobenz-aldehyde)hydrazono)nicotinyl)lysine methyl ester... 

Fig. 4 Typical radio-high-performance liquid chromatography (HPLC) chromatograms of macrocyclic 99mTc complexes [99mTc(HYNIC-Kp-DPPB)(tricine)] (top) and [99mTc(HYNIC-Ko-DPPB)(tricine)] (bottom), where HYNIC-Kp-DPPB is iST- -(2-(diphenylphosphino)ben-zoyl)-N-a-(6-(2-(2-sulfonato-benzaldehyde)hydrazono)nicotinyl)lysine methyl ester and HYNIC-Ko-DPPB is iSr- -(4-(diphenylphosphino)benzoyl)-AT-fl-(6-(2-(2-sulfonato-ben-zaldehyde)hydrazono)nicotinyl)lysine methyl ester...

In the case of the double NPS-protected lysine methyl ester, oxidation selectively takes place at the 6-sulfenamide function under spontaneous cyclization via the a-sulphe-namido group as nucleophile. Only one diastereoisomer of the A,A -bis(NPS)-protected methyl 6-amino-piperidine-2-yl-carboxylate seems to be formed. The transformation of a-amino alkanoates and diaryl or dialkyl disulfides to the aryl- or alkylsulfenimine derivatives can be performed electrochemically using MgBr2 as a mediator system. This reaction can either proceed in one step or starting from the corresponding sulfenamide [170]. 

Solvent selection can markedly influence the product ratios of a reaction. In the catalytic asymmetric aminohydroxylation of styrene, the ratio of the acetamide products rose from 0.9 1 to 6.1 1 when the reaction was run in aqueous acetonitrile instead of aqueous n-PrOH (Figure 4.11) [34]. Solvent polarity can influence asymmetric induction, particularly during peptide coupling. When the racemic azlactone 15 was condensed with L-lysine methyl ester (16, Figure 4.12), the D,L-product predominated in relatively nonpolar solvents, and the L,L-product predominated in polar solvents and at lower temperatures [35]. 

L-lysine methyl ester HC1 L-lysine ethyl ester HC1 Polyurea H — Me Mn 5,900 Polyurea R — Et Mn 17,000... 

Temperature-responsive PURs based on poly(ethylene glycol), L-lysine methyl ester diisocyanate (LDIM), or L-lysine butyl ester diisocyanate (LDIB) have been... 

Diaminobutanoic acid methyl ester, L Ornithine methyl ester, L Lysine methyl ester, L... 

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