PCL-based PURs

Finally, regarding diisocyanate selection, broad attention has been directed to aliphatic diisocyanates, for example, 1,4-butane diisocyanate (BDl), HDl, and 2,6-diisocyanate methyl caproate (LDl), due to the biocompatibility of their degradation products (as an example, BDI hydrolysis produces putrescine that is commonly present in the body and is essential for cell growth and differentiation (Skarja and Woodhouse, 2(X)0 Cooke et al., 2003)). However, aromatic diisocyanate-based PURs have also been investigated for cardiac TERM applications. Siepe et al. (2007) used the PUR Artelon (Artimplant, AB, VSslra Frblunda, Sweden), a PCL-based PUR synthesized from 1,3-diaminopropane and 4,4 -diphenylmethane diisocyanate, for the fabrication of ceUularized patches for cardiac TERM. 

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