Lysine metabolism

Fluoropyruvate inhibits an enzyme which is located on a bypass of lysine metabolism, with the result that more carbon flows towards lysine. The yield was increased to 50 g L 1. 

Tayek JA, Herber D, Chlebowski RT. 1987. Effect of hydrazine sulphate on whole-body protein breakdown measured by " C-lysine metabolism in lung cancer patients. The Lancet 241-244. 

Lysine metabolism. The pathway for the conversion of lysine to acetyl CoA is outlined... 

See also Amino Acids Not In Proteins, Metabolism of Serine, Glycine, and Threonine, Metabolism of Valine, Leucine, Isoleucine, and Lysine, Metabolism of Sulfur-Containing Amino Acids... 

An unusual feature of lysine metabolism is that the a-amino group does not equilibrate with the "nitrogen pool." Catabolism is initiated by deamination and proceeds by P oxidation. At least six variations of the P-oxidation process have been proposed. The evolutionary differences concern the manner in which the two amino groups are moved from the carbon skeleton. In the seemingly simplest pathway (A in Fig. 

In addition, the concept of linear responses to graded levels of nutrient input is not consistent with the kinetics of enzymes or enzyme systems. A curved response for individual animals would be expected just as a Michaelis-Menton relationship is expected with increasing substrate concentration for an enzyme. Curved responses have been observed when lysine a-ketoglutarate reductase activity (a simple enzyme system) and lysine oxidation to CO2 (a more complicated pathway) were measured (Blemings et al, 1994). Lysine metabolism in liver homogenates may not be directly related to whole animal responses (an animal is not a big enzyme). An animal is a system of pools and fluxes, however, and there does not appear to be a set of discrete on/off switches. 

Figure 2 Lysine metabolism and its relationship to a aminoadipic acid production in bacteria atnl fungi. Abbreviation LAT, lysine e aminotransferase.

Stadtman TC. Lysine metabolism by Clostridia. Meister A, ed. Advances in Eiuymotogy and Related Areas of Molecular Biology Voi. 38. New York John Wiley and Sons, 1973 413 48. Ohsugi M, Kahn ], Hensley C, Chew S, Barker HA, Metabolism of L 3 Iysine by a PseudomoTurs. Purification and properties of a deacetylase-thioiesierase utilizing 4-acetami-dobutyryl CoA and related compounds,] Biol Chem 1981 256 7642-7651. 

Carson, N.A.J. (1969) Saccharopinuria a new inborn error of lysine metabolism, in Enzymopenic Anemias, Lysosomes, and Other Papers (eds J.D. Allen, K.S. Holt, J.T. Ireland and R.J. Pollitt), Proc. 6th Symposium of SSIEM, Livingstone, Edinburgh, pp. 163-173. 

Zhu, X. and Galili, G. (2004) Lysine metabolism is concurrently regulated by synthesis and catabolism in both reproductive and vegetative tissues. Plant Physiol. 135, 129-136... 

In rat liver preparations no formation of 5-aminovalerate from C -pipecolic acid or lysine-6-C could be detected in the author s laboratory 160). An unknown compound that was difficult to separate chromato-graphically from 5-aminovalerate was observed. The results surest that a pathway of lysine metabolism through 6-aminovaleric acid may occur in certain bacteria but not in the mammalian organism. This has been supported by new data from the laboratory of M. Suda 167a). 

Przyrembel, H., Bachmann, D., Lombeck, I., Becker, K., Wendel, U., Wadman, S.K. and Bremer, H.J. (1975), Alpha-ketoadipic aciduria, a new inborn error of lysine metabolism Biochemical studies. Clin. Chim. Acta, 58,257. 

Gerritsen, T. and Fischer, M.H. (1976), a-Aminoadipic aciduria, a new inborn error of lysine metabolism. Proceedings of the 12th Meeting of the Society for the Study of Inborn Errors of Metabolism, Heidelberg, 1974. In Inborn Errors of Calcium and Bone Metabolism (eds. H. Bickel and J. Stern), Medical and Technical Publishing Co., Lancaster, pp. 267-270. 

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