Lysergic acid diethylamide pharmacology

Rothlin, E. (1967) Pharmacology of lysergic acid diethylamide and some of its related compounds. J. Pharm. Pharmacol., 9 569-587. 

In 1954, i.e. about 2 years after the discovery of chlorpromazine in Europe, two American biochemists (Woolley and Shaw) published the hypothesis that schizophrenia and similar psychoses could be based on a disturbance of serotoninergic neurotransmission in the brain. This hypothesis was supported by some facts that had become known shortly beforehand the spectacular psychotropic actions of LSD (lysergic acid diethylamide), which can trigger disturbances in perception, thought and feelings as well as hallucinations in healthy subjects (Stoll, 1947) and the serotonin-antagonistic effects of LSD, i.e. its ability to block the actions of serotonin in various pharmacological tests. 

Mansour, T.E. (1957) The effect of lysergic acid diethylamide, 5-hydroxytryptamine and related compounds on the liver fluke Fasciola hepatica. British journal of Pharmacology 12, 406-409. 

Wagner, J., Aghajanian, G., and Bing, O., Correlation of performance test scores with tissue concentration of lysergic acid diethylamide in human subjects, Clinical Pharmacology and Therapeutics, Vol. 9, No. 5, 1968, pp. 635 638. 

The literature on pharmacological and clinical investigations of the ergot alkaloids and their derivatives is very comprehensive. There have already been more than one-thousand reports on lysergic acid diethylamide (LSD 25) (66), which was prepared only 20 years ago the publications on the pharmacological and clinical effects of ergotamine (13, 14), which was isolated in 1918, are far greater in number. In this review it will therefore not be possible to go into details it will be based on a schematic representation provided by Cerletti (170) and further elaborated by Hofmann (171). 

Rothlin, E. Pharmacology of Lysergic Acid Diethylamide and Some of its Related Compounds J. of Pharmacy and Pharmacology (1957) 9 569-587 Rutschamann, J., Kobel, H. Obtaining Deriviatives of Lysergic Acid by a Microbiological Process Chemical Abstracts (19 ) 15314 e-g... 

---