Lymphomas splenic marginal zone lymphoma

L Splenic marginal zone lymphoma (SMZL). These tumors involve both the white and the red pulp of the spleen. In the white pulp the neoplastic cells surround or replace the germinal centers, often with effacement of the mantle cell zone, and infiltrate the marginal zone. In the red pulp the tumor cells form nodules and sheets and infiltrate the sinuses. The neoplastic lymphocytes may circulate and involve the bone marrow (H5,19). 

M26. Mollejo, M., Lloret, E., Menarguez, J., Piris, M. A., and Isaacson, P. G., Lymph node involvement by splenic marginal zone lymphoma Morphological and immunohistochemical features. Am. J. Surg. Pathol. 21, 772-780 (1997). 

R9. Remstein, E. D., James, C. D., and Kurtin, P. J., Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas. Am. J. Pathol. 156,1183-1188 (2000). 

Catovsky D, Matutes E. Splenic lymphoma with circulating villous lymphocytes/splenic marginal-zone lymphoma. Semin He-matol. 1999 36(2) 148-154. 

Savilo E, Campo E, Mollejo M, et al. Absence of cyclin D1 protein expression in splenic marginal zone lymphoma. Mod Pathol. 1998 ll(7) 601-606. 

Splenic marginal zone B-cell lymphoma ( villous lymphocytes)... 

B6. Bertoni, R, Conconi, A., Lutrdnari, S., Realini, C., Roggero, E., Baldini, L., Carobbio, S., Cavalli, R, Neri, A., and Zucca, E., Lack of CD95/FAS gene somatic mutations in extranodal, nodal and splenic marginal zone B cell lymphomas. Leukemia 14, 446-448 (2000). 

C4. Campo, E., Miquel, R., Krenacs, L., Sorbara, L., Raffeld, M., and Jaffe, E. S., Primary nodal marginal zone lymphomas of splenic and MALT type. Am. J. Surg. Pathol. 23, 59-68 (1999). 

Wu CD, Jackson CL, Medeiros LJ. Splenic marginal zone cell lymphoma. An immunophenotypic and molecular study of five cases. Am Clin Pathol. 1996 105(3) 277-285. 

Pawade J, Wilkins BS, Wright DH. Low-grade B-cell lymphomas of the splenic marginal zone a clinicopathological and immunohistochemical study of 14 cases. Histopathology. 1995 27(2) 129-137. 

Baldini L, Guffanti A, Cro L, et al. Poor prognosis in non-villous splenic marginal zone cell lymphoma is associated with p53 mutations. Br J Haematol. 1997 99(2) 375-378. 

CLL/SLL, Chronic lymphocytic leukemia/small lymphocytic lymphoma MCL, mantle cell lymphoma FL, follicular lymphoma MZL/MALT, marginal zone lymphoma/mucosa-associated lymphoid tisuse lymphoma SMZL, splenic marginal zone lymphoma HCL, hairy cell leukemia DLCL, diffuse large-cell lymphoma PCM, plasma cell myeloma BCL-1, cyclin D1 FDC MW, Follicular dendritic cell meshworks CK, cytokeratin LELs, lymphoepitheilal lesions. 

Baldini L, Eracchiolla NS, Cro LM, et al. Erequent p53 gene involvement in splenic B-cell leukemia/lymphomas of possible marginal zone origin. Blood. 1994 84(l) 270-278. 

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