Lymphogranuloma venereum serum proteins

For diagnosis in lymphogranuloma venereum, serum protein determinations are of only supplemental value since the results are neither as consistent nor as specific as is the Frei skin test. However, a positive Frei reaction does not indicate whether the disease is or is not in an active phase, whereas the serum globuUn level seems to reflect the degree of... 

Fig. 2. Relation of Howe serum albumin (upper) and total globulin (lower) fractions to total serum protein content in disease. The limits of normal variation are indicated by heavy lines forming small box solid dots indicate r ulta in lymphogranuloma venereum and other infections hollow dots indicate results in icirrhosis. From Gutman et al. (120).

The sensitivity and specificity of the quantitative precipitin method make it applicable to the identification and estimation of abnormal plasma proteins in certain diseases, particularly when present in concentrations too low to be detected by other methods. Goettsch and her associates (103, 104) and Kendall (181) employed immunochemical techniques in the study of nephrotic sera Kendall (181) also investigated the distribution of his immunologically distinct globulin subfractions in hyperglobulinemia due to lymphogranuloma venereum, cirrhosis of the liver, and rheumatoid arthritis Kabat (261) was able to demonstrate the presence of as little as 0.15 gram per cent Bence-Jones protein in the serum of a patient with multiple myeloma. Many other applications of immunochemical techniques are noted by Kabat (167) and Treffers (358) in recent reviews. 

Howe Fractionation of the Serum Proteins in Lymphogranuloma Venereum ... 

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