Lower gastrointestinal infusion

Darcy M (2003) Treatment of lower gastrointestinal bleeding vasopressin infusion versus embolization. J Vase Interv Radiol 14 535-543... 

When arginine vasopressin is used in high single doses (4—16 IU), to control upper gastrointestinal tract bleeding, gut ischemia has been reported (20). Continuous infusions at lower doses have shown changes suggestive of splanchnic hypoperfusion. 

The most important risk factors for acyclovir nephrotoxicity are intravascular volume contraction, preexisting kidney desease, and the use of a high-dose, rapid bolus intravenous infusion [7] Nephrotoxicity with oral acyclovir has been reported only rarely [23] The main non-renal toxicities of acyclovir are gastrointestinal and neurologic side effects, which primarily occur in patients on high-dose intravenous acyclovir. As acyclovir is primarily cleared by the kidney, lower intravenous doses and even oral administration can lead to neurotoxicity in patients with decreased kidney function from either CKD or AKI [15,17, 24, 25]. 

Absence of gastrointestinal disturbances, usually observed at much lower salicylic acid doses, was again striking. With infusion therapy, the blood picture, kidney and liver functions, blood sugar, serum electrophoresis, electrolyte metabolism, ECG and rheumatic serology were evaluated. No pathological changes or abnormal reactions were found. Nor were there any cerebral, respiratory, or circulatory toxicities observed. 

---