Low-signal-intensity

To overcome photobleaching and the low signal intensities of cyanine dyes Cy3 and Cy5, these dyes were encapsulated in silica coreshell nanoparticles [76]. The obtained dye-doped nanoparticles were applied in the DNA microarray-based... 

Fig. 13.6. FLAIR (top row) and T2 -weighted gradient echo images (bottom row) in a patient with hypertension showing a typical lesion pattern. Note subcortical lesions including lacunar lesions with severe tissue destruction and CSF like, low signal intensity (e.g. lateral to the anterior horn of the left lateral ventricle) on FLAIR images. On T2 -weighted images residuals from hemorrhagic lesions and small bleeds are appreciated mainly in the basal ganglia...

The results show three vertices 6, 18, and 21 with > 0.98. Although vertex 6 shows the highest obtained (r = 0.98627), the separation presented low resolution and low signal intensity. This result was probably due to the fact that the CE instrument did not have enough pressure to conduct the proper replacement of a high viscosity matrix inside the capillary at different concentrations. Vertex 18, which presented an = 0.98002, also showed low resolution and the conditions were not completely optimized compared with the results obtained in vertex 21, which was considered the best. The poor result of vertex 18 may be explained by the high salt concentration of the sample. 

Additional support for overlapping biradical 4 and bicyclopentane 5 IR bands comes from computational studies. As shown in Table 2.2, experimental IR frequencies of 5 in the C-H stretching region are reasonably reproduced by B3LYP/ 6-311 +G(2d,p) vibrational frequency calculations (scaled by 0.96) [89]. Analogous UB3LYP/6-311-+ G(2d,p) calculations on triplet biradical 4 indicate that overlap with 5 is likely for our experimentally observed 3050 and 2856 cm bands, but not for bands observed at 2968 and 2924 cm . (We were not able to collect adequate kinetic data at 2968 cm due to low signal intensity.) These... 

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