Lovastatin dosage

In the first clinical studies with lovastatin, pte-dmg semm cholesterol values of 150—300 mg/dL were shown to be decreased as much as 25% with a dosage of 15 mg twice daily for just over a week (149). Whereas the dmg shows few adverse side effects, gastrointestinal disturbances, including diarrhea and abdominal pain, ate the most common. 

Elderly In patients older than 70 years of age, the AUC of lovastatin, pravastatin, and simvastatin is increased. Pravastatin does not need dosage adjustment. The safety and efficacy of atorvastatin, rosuvastatin, and lovastatin extended-release in patients 70 years of age and older were similar to those of patients younger than 70 years of age. Elderly patients (65 years of age and older) demonstrated a greater treatment response in respect to LDL-C, total-C and LDL/HDL ratio than patients younger than 65 years of age. 

The usual recommended starting dose of lovastatin is 20 mg once/day. Make dose adjustments at intervals of 4 weeks or more. Patients already receiving a stable dose of lovastatin may receive concomitant dosage titration with niacin extended-release tablets, and switch to niacin extended-release/lovastatin tablets once a stable dose of niacin extended-release tablets has been reached. 

The effects of itraconazole 100 mg on the pharmacokinetics of lovastatin 40 mg have been studied in a randomized, placebo-controlled, crossover study in 10 healthy volunteers (16). Itraconazole, even in this low dosage, greatly increased plasma concentrations of lovastatin and its active metabolite, lovastatin acid, and increased the Cmax of lovastatin about 15-fold and the total AUC by more than 15-fold similarly, the Cmax and total AUC of lovastatin acid were increased about 12-fold and 15-fold respectively. 

St John s wort 1. Atorvastatin 2. Simvastatin 3. Lovastatin 1 blood levels and lipid-lowering effect Induction of metabolizing CYP3A4 enzymes, which metabolize simvastatin Avoid concomitant use if possible. Monitor response to simvastatin closely. Avoid sudden changes of the herb dosage... 

Another spectrophotometric method used the derivative method. Rajput and Raj [19] developed a first-order derivative zero-crossing method to analyze ezetimibe in combination with simvastatin. This method was further applied to determine ezetimibe in combination with lovastatin. The first derivation method also applied to determine ezetimibe in combination with rosuvastatin [20]. Besides the first-derivative method, second- and third-derivative methods were also reported for defermining ezetimibe as a single compound in its dosage form [21]. Flowever, the third-derivative method yielded the lowest limits of defecfion and quantitation relative to other methods used in this research. The maximum wavelength also remained constant regardless of fhe derivative method applied. 

In an open, randomized, crossover study in 12 healthy volunteers, roxithromycin did not alter the pharmacokinetics of lovastatin in such a way that dosage adjustment of lovastatin should be necessary during co-administra-tion (17). 

They suggest that a dosage reduction of the statin should be considered during concurrent use. The manufacturer of posaconazole (also a CYP3A4 inhibitor) contraindicates its use with simvastatin or lovastatin. ... 

An extended release osmotic dosage form was designed and the effect of p-cyclodextrin inclusion complexation on the solubility of lovastatin in aqueous media was investigated by Mehramizi and coworkers. [128]. The lovastatin P-cyclodextrin solid systems were prepared by kneading method. The elementary osmotic pumps (EOPs) were prepared with lovastatin P-cyclodextrin complex with cellulose acetate (CA) and polyethylene glycol as plasticizer. The... 

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