Loss of function mutant

Dominant effect at the cellular level of a recessively inherited loss-of-function mutant of a tumor suppressor gene (see Chapter 14) Retinoblastoma and RBI Li-Fraumeni syndrome and TP53... 

GA (K = 4.8 x 10 mol I 1) than the other two. The expression of each in rice gidl mutants rescued the GA-insensitive dwarf phenotype, demonstrating that AtGIDls function as GA receptors in rice.298 Multiple loss-of-function mutants of the three AtGIDls have recently shown severely dwarfed and GA-insensitive phenotypes resembling the rice gidl mutant.324-326... 

There are three additional ARRs (ARR22-24) in the Arabidopsis genome. Overexpression of ARR22 shows a similar phenotype to that of the wol mutant, a loss-of-function mutant of a cytokinin receptor, suggesting that ARR22 might be an element in the cytokinin-responsive phosphorelay signal transduction pathway.537... 

The first mutant etrl-1 isolated in the ethylene receptor genes was dominant gain-of-function mutation conferring ethylene insensitivity.952 Single receptor loss-of-function mutants essentially show no phenotype... 

Sanna, M.G. and Simon, M.I. (1996). In vivo and in vitro characterization of Escherichia coli protein GheZ gain- and loss-of-function mutants. J. Bacteriol. 178, 6275-6280. 

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