Moxonidine lorazepam

Wesnes K, Simpson PM, Jansson B, Grahnen A, Weimann HJ, Kuppers H. Moxonidine and cognitive function interactions with moclobemide and lorazepam. Eur J din Pharmacol 1997 52(5) 351-8. 

When co-administered with lorazepam 0.4 mg, moxonidine increased impairment of attentional tasks (choice, simple reaction time and digit vigilance performance, memory tasks, immediate word recall, delayed word recall accuracy, and visual tracking). These effects should be considered when moxonidine is coadministered with lorazepam, although they were smaller than would have been produced by a single dose of lorazepam 2 mg alone (26). 

The cognitive function of 24 healthy subjects was not impaired by moxonidine 400 micrograms daily, but the presence of moxonidine was found to increase the cognitive impairment caused by lorazepam 1 mg daily. For this reason the manufacturers warn that the sedative effects of the benzodiazepines may possibly be enhanced by moxonidine. Sedation and dizziness may occur with moxonidine, which the manufacturers suggest may be additive with the effects of sedatives and hypnotics. They also advise the avoidance of alcohol. ... 

Wesnes K, SimpsCTi PM, Janssoti B, Grahneti A, Wemann H-J, Ktqpeis H. Moxonidine and cc itive function interactions wi moclobemide and lorazepam. Eur J Clin Pharmacol... 

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