Loop diuretics furosemide

The loop diuretics, furosemide (Lasix) and ethacrynic acid (Edecrin), increase the excretion of sodium and chloride by inhibiting reabsorption of these ions in the... 

Loop diuretics (furosemide, bumetanide, torsemide, and ethacrynic acid) are all equally effective when given in equivalent doses. Therefore, selection is based on the side-effect profile, cost, and pharmacokinetics of the agents. The incidence of ototoxicity is significantly higher with ethacrynic acid compared to the other loop diuretics therefore, its use is limited to patients who are allergic to the sulfa component in the other loop diuretics.15 While ototoxicity is a well-established side effect of furosemide, its incidence is greater when administered by the intravenous route at a rate exceeding 4 mg per minute.16 Torsemide has not been reported to cause ototoxicity. 

The answer is c. (Hardman, pp 704-706J Triamterene produces retention of the K ion by inhibiting in the collecting duct the reabsorption of Na, which is accompanied by the excretion of K ions. The loop diuretics furosemide and bumetanide cause as a possible adverse action the development of hypokalemia. In addition, thiazides (e g, hydrochlorothiazide) and the thiazide-related agents (e.g., metolazone) can cause the loss of K ions with the consequences of hypokalemia. Triamterene can be given with a loop diuretic or thiazide to prevent or correct the condition of hypokalemia. 

Equipotent doses of loop diuretics (furosemide, bumetanide, torsemide, ethacrynic acid) have similar efficacy. Ethacrynic acid is reserved for sulfa-allergic patients. Continuous infusions of loop diuretics appear to be more effective and to have fewer adverse effects than intermittent boluses. An initial IV loading dose (equivalent to furosemide 40 to 80 mg) should be administered before starting a continuous infusion (equivalent to furosemide 10 to 20 mg/hour). 

Patients with SIADH should be treated with 3% saline plus, if the urine osmolality exceeds 300 mOsm/kg, a loop diuretic (furosemide, 40 mg IV every 6 hours). 

Patients with sodium overload should be treated with loop diuretics (furosemide, 20 to 40 mg IV every 6 hours) and 5% dextrose at a rate that decreases serum sodium by approximately 0.5 mEq/L/hour or, if hypernatremia developed rapidly, 1 mEq/L/hour. 

Thiazide diuretics are not the drugs of choice in patients with renal insufficiency. In this situation, the loop diuretics furosemide and bumetanide are recommended they have greater intrinsic natriuretic potency than do the thiazides and do not depress renal blood flow. 

Offers potential advantages over other loop diuretics, including a longer duration of action and fewer adverse electrolyte and metabolic effects available data not extensive or convincing enough at present to recommend replacement of standard loop diuretic (furosemide) considered alternative in refractory patients... 

Loop diuretics Furosemide Block Na/K/2CI transporter in renal loop of Henle Like thiazides t greater efficacy Severe hypertension, heart failure See Chapter 15... 

Ototoxicity Ototoxicity (vestibular and cochlear) is directly related to high peak plasma levels and duration of treatment. Deafness may be irreversible and has been known to affect fetuses in utero. Patients simultaneously receiving another ototoxic drug such as the loop diuretics furosemide, bumetanide, ethacrynic acid (see p. 227) or cisplatin (see p. 396), are particulary at risk. Vertigo and loss of balance may also occur because these drugs affect the vestibular apparatus. 

Q8 The thiazide diuretics reduce urinary excretion of calcium and can also be used to decrease the likelihood of calcium-based renal stones. On the other hand, the loop diuretic furosemide reduces reabsorption of calcium and increases calcium excretion. 

Loop diuretics (furosemide, bumetanide, torsemide) are usually necessary to restore and maintain euvolemia in HE. In addition to acting in the thick ascending limb of the loop of Henle, they induce a prostaglandin-mediated increase in renal blood flow that contributes to their natriuretic effect. 

PHENYTOIN LOOP DIURETICS -FUROSEMIDE l efficacy of furosemide Uncertain Be aware watch for poor response to furosemide... 

Among the agents that promote the nephrotoxic effects of the aminoglycosides, the loop diuretics furosemide and etacrynic acid are often mentioned. However, this... 

Lithium is also known to interact in a variety of ways with different classes of diuretic drugs. Thiazide diuretics increase serum lithium concentration by increasing reabsorption of lithium, along with that of sodium, in the proximal tubule. With potassium-sparing diuretics, conflicting results have been reported. Increased serum lithium concentrations may be seen after amiloride. However, the loop diuretic furosemide safely can be combined with lithium with no reduction in renal lithium clearance or consequent increase in serum lithium concentration (191, 192). Other diuretics, for example, carbonic anhydrase inhibitor and xanthine derivatives, decrease serum... 

Excessive urinary losses of magnesium from the kidneys are important causes of magnesium deficiency. Clinically important causes include alcohol, diabetes meUitus (osmotic diuresis), loop diuretics (furosemide), and aminoglycoside antibiotics. Increased sodium excretion (parenteral fluid therapy) and increased calcium excretion (hypercalcemic states) also result in renal magnesium wasting. 

Sulfonamide diuretics Hydrochlorodiiazide Chlorthalidone Loop diuretics Furosemide Ediacrynic acid Potassium-sparing diuretics Spironolactone (Aldactone) Triamterene Amiloride Uricosuric diuretics Tienihc acid... 

Loop diuretics (furosemide, bumetanide, torsemide, ethacrynic add)... 

LOOP DIURETICS Furosemide (lasix), bumetanide (bumex), and torsemide (demadex) are widely used in the treatment of heart failure. Due to the increased risk of ototoxicity, ethacrynic acid (edecrin) should be reserved for patients who are allergic to sulfonamides or who have developed interstitial nephritis on alternative drugs. 

Loop diuretics Furosemide Ethacrynic add Bumetanide, / torsemide... 

The loop diuretic furosemide (Lasix) to a client with a serum potassium level of 4.2 mEq/L. 

The home health nurse is caring for a client diagnosed with congestive heart failure (CHF) who has been prescribed the cardiac glycoside digoxin (Lanoxin) and the loop diuretic furosemide (Lasix). Which statement by the client indicates the medications are effective ... 

Anthranilic acid is used as an intermediate for production of dyes, pigments, and saccharin. Used in preparing perfumes, pharmaceuticals e.g. loop diuretics furosemide) and UV-absorber. 

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