Lomefloxacin Theophylline

Theophylline [P] Ciprofloxacin, enoxacin, and, to a lesser extent, norfloxacin inhibit theophylline metabolism gatifloxacin, levofloxacin, lomefloxacin, ofloxacin, and sparfloxacin appear to have little effect. 

Robson RA, Begg EJ, Atkinson HC, et al. Comparative effects of ciprofloxacin and lomefloxacin on the oxidative metabolism of theophylline. Br J Clin Pharmacol 1990 29 491 193. 

Fluoroquinolones are used in the treatment of purulent bronchitis and pneumonia and are hence likely to be administered concomitantly with theophylline. Drugs such as enoxacin and ciprofloxacin have been shown to reduce theophylline clearance by inhibiting metabolism. Lomefloxacin on the other hand has been shown to have no clinically significant effect on theophylline metabolism (40, 41). 

Theophylline serum levels can be markedly increased in most patients by enoxacin. Pipemidic acid and clinafloxacin probably interact similarly. Theophylline levels can also be markedly increased in some patients by ciprofloxacin, and possibly pe-floxacin. Norfloxacin, ofloxacin, pazufloxacin, or prulifloxacin normally cause a much smaller rise in theophylline levels. However, serious toxicity has been seen in few patients given norfloxacin. Fleroxacin, flumequine, gatifloxacin, gemifloxacin, levofloxacin, lomefloxacin, moxifloxacin, nalidixic acid, rufloxacin, spar-floxacin and trovafloxacin appear not to interact. 

Nix DE, Norman A, Schentag j). Effect of lomefloxacin on theophylline pharmacokinetics. Antimicrob Agents Chemother (1989) 33, 1006-8. 

Wijnands GJA, Gomel JH, Martea M, Vree TB. The effect of multiple-dose oral lomefloxacin on theophylline metabolism in man. CAesf (1990) 98, 1440 4. 

LeBel M, Valle F, St-Laurent M. Influence of lomefloxacin on the pharmacokinetics of theophylline. Antimicrob Agents Chemother (1990) 34,1254-6. 

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