Lohmann

Apart from these methods of producing the opium alkaloids of commercial importance, processes for the minor bases have been published by Merck,Hesse, Plugge and Lohmann-Siedler. ... 

More work has been done on the alkaloids of D. bicolor, Niitt, D. Menziesii, D.C., D. scopulorum, Gr. and D. Nelsonii, Gr. which, according to G. Heyl (1903), contain a mixture of alkaloids, having pharmacological properties akin to those of curare (Lohmann ) and hence named delpho-curarine. From this material he isolated a crystalline alkaloid, C23H33O7N, m.p. 184-5°, which contained methoxyl (18 per cent.). 

M. Frank-Neumann, P. Geoffroy, and J. J. Lohmann, Tetrahedron Lett. 24,1775(1983). 

Lohmann V, Koch JO, Bartenschlager R (1996) Processing pathways of the hepatitis C vims proteins. J Hepatol 24(Suppl 2) 11-19... 

Stimple M, Prolsch A, Wagner H, Lohmann-Matthes ML (1984) Infection and Immunity 46 845... 

Hanfeld V, Leistner S, Wagner G, Lohmann D, Poppe H, Heer S (1988) Pharmazie 43 677... 

Lohmann V, Komer F, Herian U, Bartenschlager R (1997) Biochemical properties of hepatitis C vims NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol 71 8416-8428... 

A major limitation in the development of anti-HCV compounds was the lack of a virus replication system. This was finally overcome with the development of a novel replicon system that directed persistent replication in a cell culture format (Lohmann et al. 1999). Using such a system, it was possible to demonstrate antiviral activity of an NS3/4A inhibitor in a cell culture assay, and demonstrate potency on par with treatment with interferon-a (Pause et al. 2003). 

Frese M, Schwarzle V, Barth K, Krieger N, Lohmann V, Mihm S, Haller O, Bartenschlager R (2002) Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology 35 694-703... 

Hofmann WP, Polta A, Herrmann E, Mihm U, Kronenberger B, Sonntag T, Lohmann V, SchonbergerB, Zeuzem S, Sarrazin C (2007) Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy. Gastroenterology I32(3) 92I-930... 

More recently, another sulfoxide sulfine photoconversion has been reported by Franck-Neumann and Lohmann. These authors have shown that the photolysis of allylsulfinylpyrazolenines (167) provides a novel route to vinyl sulfines 168, presumably via ring-opening to a-diazosulfoxides and their a-sulfinylcarbene intermediates (equation 67). 

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