Loflazepate

CijHijClFNO 784-38-3) see Cinolazepam Doxefazepam Ethyl loflazepate Flunitrazepam Flurazepam Flutazolam Midazolam Quazepam... 

P. C. Dabas, H. Erguven, M. C. Vescina, and C. N. Carducci, Stability study of ethyl loflazepate in bulk drug, solution and dosage form by LC, J. Pharm. Biomed. Anal., 70 241 (1992). 

J. P. Cano, Y. C. Sumirtapura, W. Cautreels, and Y. Sales, Analysis of the metabolites of ethyl loflazepate by gas chromatography with electron-capture detection, J. Chromatogr., 226 413 (1981). 

Increased depressive effects when taken with other CNS depressants Cimetidine raises loflazepate plasma levels Rapid dose reduction or discontinuation of loflazepate during concomitant use with tetracyclic antidepressants such as maprotiline may result in convulsive seizures, possibly due to the loss of anticonvulsant actions that suppress the pro-convulsant actions of tetracyclic antidepressants... 

Hypomania and mania have occurred in depressed pafienfs faking loflazepate... 

Ba BB, lliadis A, Cano JP. Pharmacokinetic modeling of ethyl loflazepate (Victan) and its main active metabolites. Ann Biomed Eng. 1989 17(6) 633-46. 

Chambon JP, Perio A, Demarne H, Hallot A, Dantzer R, Roncucci R, Biziere K. Ethyl loflazepate a prodrug from the benzodiazepine series designed to dissociate anxiolytic and sedative activities. Arzneimittelforschung. 1985 35(10) 1573-7. 

Murasaki M, Mori A, Noguchi T, Hada Y, Hasegawa K, Jinbo S, Kamijima K. Comparison of therapeutic efficacy of neuroses between CM6912 (ethyl loflazepate) and diazepam in a double-blind trial. Prog Neuropsychopharmacol Biol Psychiatry. 1989 13(1-2) 145-54. 

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