Local dermal inflammation

The results are evaluated in comparison to controls with regard to induction of erythema and skin oedema. A similar scoring system is used as in the case of dermal irritation. The signs of local dermal inflammation determine the degree of the allergenic potential (Draize 1944 OECD 1981 Klecak 1983). 

Im et al. formulated monoolein-based cubic crystalline phase and its nanoparticle system of oregonin and hirsutanonol (both diarylheptanoid derivatives) to treat atopic dermatitis [91]. Diarylheptanoids have a therapeutic effect on the dermal inflammation as selective 5-hpoxygenase inhibitor and thus are expected to be applicable for atopic dermatitis [91]. For the effective treatment of atopic dermatitis with topical administration of therapeutics, penetration and accumulation of the agent into the relevant layers of the skin is required. Therefore, Im et al. explored the localization factors for local skin delivery of oregonin and... 

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