Local anesthetic INDEX

F Barbato, MI La Rotonda, F Quaglia. Chromatographic indexes on immobilized artificial membranes for local anesthetics relationships with activity data on closed sodium channels. Pharm Res 14 1699—1705, 1997. 

Documented effects Hemolytic index of the herb is equal to 1 1450, of the roots 1 4000, and the seeds contain 3.18 % of a poisonous saponin with a high hemolytic index (1 50,000 in human blood and 1 25,000 in dog s blood). Convolvine and convolamine act as local anesthetics. However, because they are highly toxic and not very effective, they are not used for this purpose. After modification, a derivative of convolamine, convocaine, was introduced for use in hospitals (Ogolevitz 1951). Peptides isolated from the seeds exhibited estrogen-like activity and caused uterine contractions in vitro (Morita et al. 1997a, b). 

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