Lobeline hydrochloride

Dose. Lobeline hydrochloride was formerly given intramuscularly in doses of 3 to 10 mg. 

Today, Lobelia inflata (Indian tobacco) or its derivatives (lobeline hydrochloride and lobeline sulfate) are used for much the same purpose and are marketed throughout Europe in a number of multi-ingredient preparations 73 Similarly, Poly gala senega (Seneca snakeroot), listed in the supply table as an expectorant, is widely marketed throughout Europe and South Africa for respiratory-tract complaints 7 A popularly prescribed diuretic on the supply table was Juniperus communis (juniper) it is still widely manufactured and dispensed for the same purpose today75... 

Barlow, R.B., Johnson, O., 1989. Relations between structure and nicotine-like activity X-ray crystal structure analysis of (- )-cytisine and (- )-lobeline hydrochloride and a comparison with ( - )-nicotine and other nicotine-like compounds. Br. J. Pharmacol. 98, 799-808. 

Glaser, R., Hug, P., Drouin, M., Michel, A., 1992. Solution- and solid-state stereochemistry of ( — )a-lobeline hydrochloride and hydrobromide, a respiratory stimulant. J. Chem. Soc. Perkin Trans., pp. 1071-1079. 

The oscillopolarography of lobeline hydrochloride has been studied. Some arecaidine quaternary salts have been shown to exhibit muscarine-like activity. ... 

Hydrochloric acid cannot be used in place of sulphuric acid, since lobeline hydrochloride is extracted from aqueous solution by chloroform. 

In water lobeline hydrochloride has an absorption maximum at 249 m/i, E(1 per cent, 1 cm) 375. This maximum is suitable for use for its determination when mixed with various bacteriostats (see p. 519). 

Injection of Lobeline Hydrochloride, JB.P.C. This is a sterile solution of lobeline hydrochloride, usually 0 3 per cent, in water for injection. 

Dilute 4 ml of injection solution to 100 ml in water. Dilute 10 ml of this solution to 100 ml in water. Measure the maximum extinction of a 1-cm layer at about 249 m/i using water as blank. Calculate the amount of lobeline hydrochloride in each ml of injection. 

To 5 ml add 10 ml of a 5 per cent w/v solution of silicotungstic acid in water allow to stand overnight. Collect the precipitate, wash with N hydrochloric acid until the washings yield no reaction with a 1 per cent w/v solution of quinine hydrochloride in water. Dry at 80° for one hour, ignite, cool, re-ignite with a few drops of nitric acid and weigh. 1 g of residue = 0 4598 g lobeline hydrochloride. 

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