Liver hepatomegaly

An enlarged liver (hepatomegaly) and spleen (splenomegaly) may be present. 

The liver hepatomegaly, hyperlipidemia, and histological changes in the liver, including increased coUagen formation. Alcohol potentiates the hepatotoxicity of vitamin A. 

In correlation with fatty infiltration, the fatty liver shows a diffuse reduction in density with decreased Hounsfield units. The fatty liver appears much darker than the spleen (so-called grey liver). Hepatomegaly with smooth contours is visible. The parenchyma is iso-dense or hypodense compared with the vessels and bile ducts, which is why (depending on the degree of fatty infiltration) there is a reversal of density (so-called negative scan ). A linear correlation exists between the extent of the fatty infiltration and the decrease in the density recorded. An increase in the relative fat content by 10% leads to a reduction in density of 17(-20) HU. 

This clinical picture is also caused by animal protein deficiency. However, it was common practice in the affected regions to use beaver oil as a laxative, and this is known to be extremely toxic to the liver. Fatty liver, hepatomegaly and jaundice were observed ultimately, cirrhosis of a more biliary type developed. 

Typical signs and symptoms of hepatitis include jaundice (yellow discoloration of the skin and sclera of the eyes, dark urine and pale stools), anorexia (loss of appetite), an enlarged, tender liver (hepatomegaly), abdominal pain and tenderness, nausea and vomiting, and fever, although the disease may range in severity from subclinical to fulminant. 

VI Liver glycogen phosphorylase Liver Hepatomegaly, mild hypoglycemia, good prognosis... 

X cAMP-dependant Protein kinase A Liver Hepatomegaly. 

Liver Hepatomegaly Cytolysis (ALAT, ASAT in creased) reduced protein synthesis coagulation defect... 

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