Liver glycogen breakdown

Figure 21.14 Pathway Integration Hormonal control of glycogen breakdown. Glucagon stimulates liver glycogen breakdown when blood glucose is low. Epinephrine enhances glycogen breakdown in muscle and the liver to provide fuel for muscle contraction.

The increase in cAMP is a hormonal message which has an effect in two major target organs, liver and muscle, but different hormones affect increased cAMP in each. In the liver, the hormone is glucagon, whereas in the muscle, the hormone is epinephrine. In the liver, glycogen breakdown (i.e., glycogenolysis) can serve as a source of hexose phosphate, a precursor of blood glucose in the... 

In the liver, glycogen breakdown and gluconeogenesis would occur. In the muscle, glycogen breakdown and glycolysis would occur. 

Glucagon Gs-cAMP-A kinase glycogen breakdown (muscle), gluconeogenesis (liver)... 

Glycogen synthesis in liver and muscle Glycogen breakdown in liver Fat synthesis in liver Fat breakdown in adipose tissue Protein synthesis in muscle Protein breakdown in muscle... 

It increases glycogen breakdown in liver, resulting in an increased rate of release of glucose by the liver which... 

Not surprisingly, the intake of sufficient carbohydrate to satisfy this demand is vital. If carbohydrate intake is low, glucose is provided in the short term (<24 hours in the adult) by breakdown of liver glycogen. After this period, glucose must be synthesised via the process of gluconeo-genesis primarily from amino acids released from the breakdown of muscle protein and from glycerol released... 

Glucagon stimulates glycogen breakdown and simultaneously inhibits glycogen synthesis in the liver. 

Net glycogen breakdown enables the liver to secrete glucose to provide for the energy needs of much of the body, particularly the brain. 

Raise of blood pressure, contraction of smooth muscles, glycogen breakdown in liver, lipid breakdown in adipose tissue... 

Different metabolic patterns in different organs. For glycogen phosphorylase, the isozymes in skeletal muscle and liver have different regulatory properties, reflecting the different roles of glycogen breakdown in these two tissues. 

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