Little, William

A little earlier, in 1815, the London based physician, William Prout, proposed another general principle. In a few papers, which he published anonymously, Prout wrote that the fact that the atomic weights of many elements seemed to be integral multiples of the weight of hydrogen suggested that all... 

The C-nitrosation of aromatic compounds is characterized by similar reaction conditions and mechanisms to those discussed earlier in this section. The reaction is normally carried out in a strongly acidic solution, and in most cases it is the nitrosyl ion which attacks the aromatic ring in the manner of an electrophilic aromatic substitution, i. e., via a a-complex as steady-state intermediate (see review by Williams, 1988, p. 58). We mention C-nitrosation here because it may interfere with diazotization of strongly basic aromatic amines if the reaction is carried out in concentrated sulfuric acid. Little information on such unwanted C-nitrosations of aromatic amines has been published (Blangey, 1938 see Sec. 2.2). 

For substituted anilines (Thompson and Williams, 1977) and for 1-naphthylamine and a series of derivatives thereof (Castro et al., 1986a), k2 and the ratio Ar 2/Ar3 have been determined for nucleophilic catalysis with Cl-, Br-, SCN-, and SC(NH2)2. The values of k2 correspond fairly well to those found for the diazotization of aniline, but those of Ar 2/Ar3 increase markedly in the above sequence (Table 3-1). As k3 is expected to be independent of the presence of Cl- or Br- and to show little dependence on that of SCN- or thiourea, the increase in k 2/k3 for this series must be due mainly to 2. Indeed, the value of log(Ar 2/Ar3) shows a linear correlation with Pearson s nucleophilicity parameter n (Pearson et al., 1968). This parameter is based on nucleophilic substitution of iodine (as I-) in methyl iodide by various nucleophiles. The three investigations on nucleophilic catalysis of diazotization demonstrate that Pearson s criteria for bimolecular nucleophilic substitution at sp3 carbon atoms are also applicable to substitution at nitrogen atoms. 

ADEL F. SAROFIM, Massachusetts Institute of Technology ROBERT S. SCHECHTER, University of Texas, Austin WILLIAM R. SCHOWALTER, Princeton University L. E. SCRIVEN, University of Miimesota JOHN H. SEINFELD, California Institute of Technology JOHN H. SINFELT, Exxon Research and Engineering Company LARRY F. THOMPSON, AT T Bell Laboratories KLAUS D. TIMMERHAUS, University of Colorado ALFRED E. WECHSLER, Arthur D. Little, Inc. 

Since HC is such a progressive disorder with clear neuronal loss, it is not surprising that NT manipulation has been of little value in therapy and that there is no drug treatment of any significance. More hope rests on a genetic approach and the mutated gene has in fact been identified and cloned but its precise role remains uncertain. For details of its structure, possible actions and appropriate models see Reddy, Williams and Tagle (1999). 

Fully hardened cements have brittle characteristics (Williams Smith, 1971 Skibell Shannon, 1973) and show little creep under load (Wilson Lewis, 1980). When mixed to a luting (cementation) consistency, their compressive strength reaches 70 to 131 MPa after 24 hours (Wilson, 1975b) depending on brand (Table 6.4). There is little subsequent increase in strength (Paffenbarger, Sweeney Isaacs, 1933 Smith, 1977). 

Diisopropyl methylphosphonate has not been shown to be amenable to biodegradation. Little if any degradation by indigenous bacteria occurred in soil "dosed" with radiolabelled diisopropyl methylphosphonate (Williams et al. 1989). Biodegradation by aquatic microorganisms has been shown to be equally ineffective (Spanggord et al. 1979 Van Voris et al. 1987), rendering it inappropriate as a means for the disposal of diisopropyl methylphosphonate. 

In 1936Kay Pryor graduated from the Slade, and decided that the development of his painting would be best served by moving to Paris. He had never been as deeply concerned with the day-to-day work of the Solmani Press as his younger brother, Gareth, and his departure made little difference to the running of it. But, as William wrote in a letter to Beatrice Webb,... 

Aurifontina chymica or, a collection of fourteen small treatises concerning the first matter of philosophers for the discovery of their (hitherto so much concealed) Mercury. Which many have studiously endeavoured to hide, but these to make manifest, for the benefit of mankind in general. London Printed for William Cooper, at the Pelican in Little-Britain, 1680. [22], 272, [4] p. 

Antonie, Bernhard Earl of Trevisan, Sir Geo. Ripley, Rog. Bacon, Geo. Starkey, Sir Hugh Platt, and the tomb of Semiramis, see more in the contents. London Printed for William Cooper, at the Pelican in Little Britain, 1684. [6], 193, [4], 32 p. 

Digby, Kenelm. Of bodies, and of mans soul. To discover the immortality of reasonable souls. With two discources Of the powder of sympathy, and Of the vegetation of plants.. . . London Printed by S.G. and B.G. for John Williams, and are to be sold in Little Britain over against St. Buttolphs-Church, 1669. 439, 23 lp. 

London. Printed by Richard Cotes and are to sold by Thomas Williams at the Bible in Little- Britain without Aldersgate, 1651."... 

Mystagogus, Cleidophorus. Mercury s caducean rod or, the great and wonderful office of the universal mercury, or God s vicegerent (sic ), displayed. Wherein is shewn his nativity, life, death, renovation and exaltation to an immutable state to which is added a general epistle discovering the mysterious fire of Pontanus. By. The second edition. 2nd ed ed. 1702 reprint, London Printed by William Pearson, for Thomas Ballard, at the Rising Sun in Little Britain, 1704. 76, 32p. 

Philalethes, Eirenaeus. A breviary of alchemy or a commentary upon Sir George Ripley s recapitulation being a paraphrastical epitome of his twelve gates. Written by Aeyrenaeus Philalethes Anglus, Cosmopolita. London Printed for William Cooper at the Pellican in Little Britain, 1678. [2], 28 p. 

Philalethes, Eirenaeus. Ripley reviv d or, an exposition upon Sir George Ripley s Hermetico poetical works. Containing the plainest and most excellent discoveries of the most hidden secrets of the ancient philosophers, that were ever published. Written by Eirenaeus Philalethes an Englishman, stiling himself Citizen of the world. London Printed by Tho. Ratcliff and Nat. Thompson, for William Cooper at the Pelican in Little-Britain, 1678. [12], 47, [1], 389, [3], 10, 28, [1], [2], 25, [6] p. 

Philalethes, Eirenaeus. "The secret of the immortal liquor called alkahest, or ignis-aqua. .. communicated to his friend, a Son of Art, and now a Philosopher. By question and answer." In Collectanea chymica, ed. William Cooper, 2]-23. London Printed for William Cooper, at the Pelican in Little Britain, 1683. 

London, Printed for William Cooper, at the Pelican in Little Britain. 1683. rhttp //www.levitv.com/alchemy/bosom.html1. 

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