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Lithium reducing agent

LiAlH4, lithium tetrahydridoaluminate ("lithium aluminium hydride . so-called) is an excellent reducing agent in ether solution for both organic and inorganic compounds it may be used to prepare covalent hydrides SiH ether, for example... [Pg.115]

The tetrahydridoborate ion, as "sodium borohydride" NaBH is soluble in water and is similarly an excellent reducing agent in this solvent. (Lithium tetrahydridoaluminate cannot be used in water, with which it reacts violently to give hydrogen.)... [Pg.115]

Lithium aluminium hydride, LiAlH, is a very active reducing agent, and is used particularly for the ready reduction of carboxylic acids (or their esters) to primary alcohols R-COOH -> R CH,OH. [Pg.155]

Some of the functional groups which are reduced by lithium aluminium hydride, the reduction product together with the theoretical mols of reducing agent required (in parenthesis) are listed below —... [Pg.878]

The reaction of an alkyl halide with lithium is an oxidation-reduction reac tion Group I metals are powerful reducing agents... [Pg.589]

For most laboratory scale reductions of aldehydes and ketones catalytic hydro genation has been replaced by methods based on metal hydride reducing agents The two most common reagents are sodium borohydride and lithium aluminum hydride... [Pg.628]

Carboxylic acids are exceedingly difficult to reduce Acetic acid for example is often used as a solvent in catalytic hydrogenations because it is inert under the reaction con ditions A very powerful reducing agent is required to convert a carboxylic acid to a pri mary alcohol Lithium aluminum hydride is that reducing agent... [Pg.632]

Reduction to alcohols (Section 15 2) Aide hydes are reduced to primary alcohols and ketones are reduced to secondary alcohols by a variety of reducing agents Catalytic hydrogenation over a metal catalyst and reduction with sodium borohydride or lithium aluminum hydride are general methods... [Pg.713]

Lithium aluminum hydride reduction (Sec tion 15 3) Carboxylic acids are reduced to primary alcohols by the powerful reducing agent lithium aluminum hydride... [Pg.810]

Lithium borohydride is a more powerful reducing agent than sodium borohydride, but not as powerful as lithium aluminum hydride (Table 6). In contrast to sodium borohydride, the lithium salt, ia general, reduces esters to the corresponding primary alcohol ia refluxing ethers. An equimolar mixture of sodium or potassium borohydride and a lithium haUde can also be used for this purpose (21,22). [Pg.301]

Lithium hydride is perhaps the most usehil of the other metal hydrides. The principal limitation is poor solubiUty, which essentially limits reaction media to such solvents as dioxane and dibutyl ether. Sodium hydride, which is too insoluble to function efficiently in solvents, is an effective reducing agent for the production of silane when dissolved in a LiCl—KCl eutectic at 348°C (63—65). Magnesium hydride has also been shown to be effective in the reduction of chloro- and fluorosilanes in solvent systems (66) and eutectic melts (67). [Pg.23]

Most classical reducing agents leave the pyrimidine nucleus unaffected, as does sodium borohydride lithium aluminium hydride usually gives a di- or tetra-hydro derivative, according to substituent(s) present (70HC(16-S1)322). [Pg.75]

NaBH4, H0(CH2)20H, 40°, 18 h, 87% yield. Lithium aluminum hydride can be used to effect efficient ester cleavage if no other functional group is present that can be attacked by this strong reducing agent. ... [Pg.162]

Polymers containing 90-98% of a c 5-1,4-structure can be produced using Ziegler-Natta catalyst systems based on titanium, cobalt or nickel compounds in conjuction with reducing agents such as aluminium alkyls or alkyl halides. Useful rubbers may also be obtained by using lithium alkyl catalysts but in which the cis content is as low as 44%. [Pg.290]

Metal-ammonia solutions reduce conjugated enones to saturated ketones and reductively cleave a-acetoxy ketones i.e. ketol acetates) to the unsubstituted ketones. In both cases the actual reduction product is the enolate salt of a saturated ketone this salt resists further reduction. If an alcohol is present in the reaction mixture, the enolate salt protonates and the resulting ketone is reduced further to a saturated alcohol. Linearly or cross-conjugated dienones are reduced to enones in the absence of a proton donor other than ammonia. The Birch reduction of unsaturated ketones to saturated alcohols was first reported by Wilds and Nelson using lithium as the reducing agent. This metal has been used almost exclusively by subsequent workers for the reduction of both unsaturated and saturated ketones. Calcium has been preferred for the reductive cleavage of ketol acetates. [Pg.27]

An isolated acetoxyl function would be expected to be converted into the alkoxide of the corresponding steroidal alcohol in the course of a metal-ammonia reduction. Curiously, this conversion is not complete, even in the presence of excess metal. When a completely deacetylated product is desired, the crude reduction product is commonly hydrolyzed with alkali. This incomplete reduction of an acetoxyl function does not appear to interfere with a desired reduction elsewhere in a molecule, but the amount of metal to be consumed by the ester must be known in order to calculate the quantity of reducing agent to be used. In several cases, an isolated acetoxyl group appears to consume approximately 2 g-atoms of lithium, even though a portion of the acetate remains unreduced. Presumably, the unchanged acetate escapes reduction because of precipitation of the steroid from solution or because of conversion of the acetate function to its lithium enolate by lithium amide. [Pg.43]

A much more stereoselective and milder reducing agent is lithium tri-r-... [Pg.162]

A mixture of lithium aluminum deuteride and aluminum chloride is a more powerful reducing agent than lithium aluminum deuteride itself. This is well illustrated by the opening of ring F in 5a-spirostan [(230) (231)] which otherwise is quite stable to lithium aluminum deuteride. The resulting 22-di-26-hydroxy-5a-furostan (231) exhibits better than 97% isotopic purity. [Pg.205]

Semicarbazones are used as protecting groups as a consequence of their stability to reducing agents such as potassium borohydride, sodium boro-hydride and lithium borohydride. Semicarbazones are cleaved by strong acids and by heating in acetic anhydride-pyridine. " ... [Pg.387]


See other pages where Lithium reducing agent is mentioned: [Pg.252]    [Pg.252]    [Pg.241]    [Pg.112]    [Pg.127]    [Pg.527]    [Pg.308]    [Pg.329]    [Pg.300]    [Pg.304]    [Pg.305]    [Pg.305]    [Pg.10]    [Pg.108]    [Pg.29]    [Pg.29]    [Pg.30]    [Pg.67]    [Pg.138]    [Pg.154]    [Pg.336]    [Pg.178]    [Pg.208]    [Pg.55]    [Pg.21]    [Pg.21]    [Pg.26]    [Pg.38]    [Pg.62]    [Pg.69]    [Pg.162]   
See also in sourсe #XX -- [ Pg.25 , Pg.26 ]




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Lithium aluminum hydride reducing agent for

Lithium aluminum hydride reducing agent for aldehydes and ketones

Lithium as reducing agent

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Lithium reducing agent, acting

Reducing agent

Reducing agents lithium aluminium hydride

Reducing agents lithium aluminum hydride

Reducing agents lithium tetrahydridoaluminate

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