Spironolactone Lisinopril

Cardiovascular Acetyldigosin, ajmaline, amiodarone, aprindine, bepridil, bezaflbrate, captopril, dinepazide, clopidogrel, coumarins, diazoxide, digoxin, dipyridamole, disopyramide, doxazosin, enalapril, flurbiprofen, fur-oxemide, hydralazine, lisinopril methyldopa, metolazone, nifedipine, phenindione, procainamide, propanolol, propafenone, quinidine, ramapril, spironolactone, thiazide diuretics, ticlopidine, vesnarinone... 

A 67-year-old man, who had taken amiodarone 200 mg/ day for 3 months, developed hyponatremia (serum sodium concentration 117 mmol/1) (27). He was also taking furosemide 20 mg/day, spironolactone 25 mg/ day, and lisinopril 40 mg/day. His urine osmolality was 740 mosmol/kg with a normal serum osmolality. Fluid restriction was ineffective, but when amiodarone was withdrawn the sodium rose to 136 mmol/1. 

Clinically important, potentially hazardous interactions with ACE inhibitors, benazepril, captopril, cyclosporine, enalapril, fosinopril, lisinopril, magnesium, moexipril, potassium salts, quinapril, quinidine, ramipril, spironolactone, trandolapril, zofenopril... 

Note Aldactazide is spironolactone and hydrochlorothiazide Aldoril is methyldopa and hydrochlorothiazide Avalide is irbesartan and hydrochlorothiazide Capozide is captopril and hydrochlorothiazide Dyazide is triamterene and hydrochlorothiazide Maxzide is triamterene and hydrochlorothiazide Moduretic is amiloride and hydrochlorothiazide Prinizide is lisinopril and hydrochlorothiazide... 

A. Rochetaing, C. Chapon, L. Marescaux, A. Le Bouil, A. Furber, P. Kreher. Potential beneficial as well as detrimental effects of chronic treatment with lisinopril and (or) spironolactone on isolated hearts following low-flow ischemia in normal and infarcted rats, Can. J. Physiol. Pharmacol. 81, 864-872 (2003). 

A 90-year-old male patient with HTN is being treated with furosemide, lisinopril, and spironolactone. Because of a fainting spell, he is brought to the ER, where his BP supine is 105/60, falling to 65/42 when he is asked to sit up. Which one of the following statements about the case is most reasonable ... 

A report describes a 74-year-old woman with increased lithium levels of 2.3 mmol/L and symptoms of lithium toxicity, which were associated with several drugs including irbesartan, lisinopril, escitalopram, levomepro-mazine, furosemide and spironolactone. It was suggested that these drugs could have delayed lithium excretion or worsened neurotoxic effects. An increase in the lisinopril dose and the addition of irbesartan several weeks before admission may have contributed to the lithium toxicity. ... 

Electrolyte balance Hypernatremia has been reported in a 44-year-old woman with normal renal function who was given too much sodium polystyrene sulfonate she was also taking furosemide, spironolactone, and lisinopril [39 ]. The authors attributed this to net intestinal water loss because of profuse osmotic diarrhea. 

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