Liquid Filling and Closing Machine

To describe the procedure for validation of the liquid filling and closing machine to ensure that it meets installation, operational, and performance qualification requirements 

It is the responsibility of the production manager and technical services manager to follow the procedure. The quality assurance manager is responsible for SOP compliance. 

Control panel Feeding of empty bottles Detector for presence of bottles Detector for presence of liquid Terminal sterile filter unit Filling unit 

Detector for correct liquid level in the bottle Feeding of bottles to the closing machine Detector for presence of filled bottles Feeding of dropper and pouring ring (if applicable) 

Detector for presence of dropper or pouring ring prior to closing Feeding of closures Screwing unit 

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