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Liquid Chromatography Pharmaceutical profiling

Kerns, E. H., Di, L., Pemsky, S., Kleintop, T., Huryn, D., McConnell, O., Carter, G. Pharmaceutical profiling method for lipophilidty and integrity using liquid chromatography-mass spectrometry. [Pg.353]

Since its creation around 1973, modern high-pressure liquid chromatography (HPLC) has played a dominant role in the analysis of pharmaceuticals. It is used in many different applications for example, in content uniformity assays and stability-indicating methods, for the purity profiles of drug substances, or in the analysis of drug metabolism in animals and humans. The heart of all of these assays is the HPLC column. In this chapter, we will describe the fundamental properties of HPLC columns as well as how these properties influence column performance and separation characteristics in pharmaceutical assays. [Pg.78]

Nuijen B, Rodrigues-Campos IM, Noain CP, et al. (2001) HPLC-UV method development and impurity profiling of the marine anticancer agent aplidine in raw drug substance and pharmaceutical dosage form. Journal of Liquid Chromatography and Related Technologies 24 3119-3139. [Pg.2729]

In the pharmaceutical industry, separation of enantiom has been a field of growing interest because they often display quite different pharmacological activities and toxicity profiles. Resolution of enantiomers by liquid chromatography is very frequently used for determining the optical purity and for obtaining individual enantiomers of the dmgs. [Pg.101]

See other pages where Liquid Chromatography Pharmaceutical profiling is mentioned: [Pg.320]    [Pg.126]    [Pg.146]    [Pg.500]    [Pg.485]    [Pg.246]    [Pg.712]    [Pg.243]    [Pg.224]    [Pg.465]    [Pg.501]    [Pg.243]    [Pg.5]    [Pg.399]    [Pg.181]   
See also in sourсe #XX -- [ Pg.440 ]



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