Liquid carbon dioxide, use

In spite of this critical note, the potential of SFC in analytical and preparative-scale enan-tioseparations has been already illustrated. Technical development in this field may open even more challenges for this technique. The advantage of SFC for preparative separations is that the high-pressure liquid carbon dioxide used as mobile phase can easily be removed from the product. In addition, carbon dioxide is non-hazardous and relatively inexpensive. On the other hand, this mobile phase creates the following problems the solubility of polar compounds is limited, and alcohols or other polar modifiers have to be used. Although this makes the technical advantage of SFC questionable, the method may offer some advantages for chiral compounds that may dissolve in SFC mobile phases. Selected examples of preparative SFC enantioseparations are summarized in Table 10 [168-171]. 

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