Lippia dulcis Verbenaceae

Hydroxy-hernandulcin (sesquiterpene) Lippia dulcis (Verbenaceae) [flower, leaf] Sweet... 

Aloenin (= 4-Methoxy-6-(2-(3- Verbascum sinuatum (Scrophulariaceae), Lippia dulcis (Verbenaceae) Acanthaceae, Bignonaceae, Gesneriaceae, Oronbranchaceae, Plantaginaceae Aloe arborescens (Liliaceae) Bitter [inhibits gastric... 

The sesquiteipene hemandulcin (83) from Lippia dulcis (Verbenaceae), a plant used as a sweetener by the Aztecs, is more than 1000 times sweeter than sucrose (Compadre et al., 1985, 1987). 

Sweet sesquiterpenoids (-F)-hernandulcin, 6-(1,5-dimethyl-1-hydroxyhex-4-en-l-yl)-3-methylcyclohexen-2-one, and (-F)-4P-hydroxyhernandulcin (11-35) occur at a level of about 0.04% in the sweet herb Phyla dtdds (syn. Lippia dulcis, Verbenaceae) native to tropical Central and South America. Leaves with the sweet taste (hemandulcin is about 1250 times sweeter than saccharose) are used in traditional medicine. Because of its slightly bitter taste and minty after-taste, hemandulcin has only limited use as a sweetener. 

Hernandulcin is a bisabolane sesquiterpene isolated from the herb Lippia dulcis Trev. (Verbenaceae), which is native to Mexico, and has been reported to be 1500 times sweeter than sucrose.44 45 The natural product has a 6S, 1 xS" configuration, and of the four possible stereoisomers, only this one has intense sweetness.46 47 Another sweet substance, 4,3-hydn> x v hern a n d u I cm, was isolated from a sample native to Panama.46 The sweetness and bitterness of hernandulcin have been reported to linger in the mouth for sometime. This compound is rather thermolabile. 

Lippia dulcis (family Verbenaceae) This produces a compound from the leaves and flowers that is 1000 times sweeter than sucrose. 

Fischer, U., 1998. Variabilitat Guatemaltekischer Arzneip anzen der Gattung Lippia (Verbenaceae) Lippia alba, L. dulcis, L. graveolens. Dissertation, Veterinarmedizinischen Universitat, Wien, Austria. Fischer, U., Ch. Franz, R. Lopez, and E. Poll, 1996. Variability of the essential oils of Lippia graveolens HBK from Guatemala. In Essential Oils Basic and Applied Research, Ch. Franz, A. Mathe, and A.G. Buchbauer (eds.), pp. 266-269. Carol Stream, IL Allured Publishing. 

Fischer, U., 1998. Variabilitiit Guatemaltekischer Arzneipflanzen der Gattung Lippia (Verbenaceae) Lippia alba, L. dulcis, L. graveolens. Dissertation, Veterinarmedizinischen Universitat, Wien. 

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