Liposomes transferrin receptor

Gosk, S., et al. 2004. Targeting anti-transferrin receptor antibody (0X26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion. J Cereb Blood Flow Metab 24 1193. 

Immunoliposomes (3) DNA + pegylated liposomes targeted to the transferrin receptor No limit Ciliary body, iris, corneal epithelium >48 hr NR Transferrin receptor NR... 

Kobayashi T, Ishida T, Okada Y, Ise S, Harashima H, Kiwada H. Effect of transferrin receptor-targeted liposomal doxorubicin in p-glycoprotein-mediated drug resistant tumor cells. Tnt J Pharm 2007 329 94—102. 

MBP-426 Liposome Oxaliplatin Active (Transferrin receptor) Colon cancer Phase 1 clinical trials ... 

Chiu S, Liu S, Perrotti D et al (2006) Efficient delivery of a Bcl-2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor-targeted liposomes. J Control Release 112 199-207... 

Voinea, M., Binding and uptake of transferrin-bound liposomes targeted to transferrin receptors of endothelial cells, Vascul. Pharmacol, 39,13, 2002. 

Transferrin receptors are found on many mammalian cells and transferrin as a ligand is used for delivery of dmgs, liposomes, and macromolecules [55] however, use of transferrin in chitosan has rarely been reported. 

Cheng, P. W. Receptor ligand-facilitated gene transfer Enhancement of liposome-mediated gene transfer and expression by transferrin. Hum. Gene Ther. 7 275—282, 1996. 

Liposomes can be targeted to the brain by exploiting receptor-mediated transcytosis systems. For example, a bi-functional PEG-linker has been used to couple anti-transferrin (0X26) receptor antibodies to one end of the PEG strands and liposomes at the other end of the PEG strands (Figure 13.6). Classically, immunoliposomes are prepared by attaching the MAb to the surface of the liposomes (see Section 5.3.1.3). However, this can lead to steric hindrance by the PEG strands with respect to antibody binding to the appropriate receptor. The use of the bifunctional PEG linker overcomes this problem. 

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