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Anti-target

Karpovsky, B., Titus, J A., Stephany, D A., and Segal, D. M (1984) Production of target-specific effector cells using hetero-cross-linked aggregates containing anti-target cell and anti-Fcy receptor antibodies. J Exp Med 160, 1686-1701... [Pg.132]

Fig. 13.1 The potassium hERG channel as anti-target within drug discovery, (a) Homology model of hERG channel with compound MK-499 bound [2]. (b) Histamine HI antagonist terfenadine, which was found to be a strong blocker of the hERG channel inducing... Fig. 13.1 The potassium hERG channel as anti-target within drug discovery, (a) Homology model of hERG channel with compound MK-499 bound [2]. (b) Histamine HI antagonist terfenadine, which was found to be a strong blocker of the hERG channel inducing...
GPCR Anti-target Modeling. Pharmacophore Models to Avoid GPCR-mediated Side-effects... [Pg.284]

Table 13.1 Biogenic amine binding GPCR anti-targets and side-effects mediated by high-affinity antagonists of the respective receptor ... Table 13.1 Biogenic amine binding GPCR anti-targets and side-effects mediated by high-affinity antagonists of the respective receptor ...
GPCR Anti-target Pharmacophore Modeling the aIo Adrenergic Receptor 285... [Pg.285]

CPCR Anti-target Pharmacophore Modeling the a,a Adrenergic Receptor... [Pg.287]

Validation of Anti-target Pharmacophore Models 13.3.3.1 Virtual Screening Hit Rates and Yields... [Pg.289]

The purpose of the anti-target pharmacophores is to recognize and rationalize anti-target side-affinities within chemotypes different from those used in the training set. Hence it appears crucial to validate the pharmacophore hypotheses using external test set molecules, which have not been used for pharmacophore... [Pg.289]

CPCR Anti-target Modeling Pharmacophore Models to Avoid CPCR-mediated Side-effects 283... [Pg.388]

In Silico Tools for GPCR Anti-target Modeling 285... [Pg.388]

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See also in sourсe #XX -- [ Pg.283 ]

See also in sourсe #XX -- [ Pg.84 ]

See also in sourсe #XX -- [ Pg.55 , Pg.56 , Pg.60 , Pg.68 , Pg.69 , Pg.71 , Pg.72 , Pg.101 ]



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