Liposomal Vaccination System for Immunity-Modulating Antitumor Therapy

Development of a Liposomal Vaccination System for Immunity-Modulating Antitumor Therapy 

Pharmaceutical Technology Development Formulation Liquids, F. Hoffmann-La Roche Ltd., Basel, Switzerland 

Klinikum Geb. 302T/TVZ Johannes Gutenberg-Universitat Mainz, 

Lehrstuhl fur Pharmazeutische Technologic, Friedrich-Schiller-Universitat Jena, 

About a 100 years ago, Coley observed tumor regression after application of a mixture of bacterial toxins. This experiment made the foundation of immune therapy for cancer, which only recently became a promising treatment and an efficient alternative to chemotherapy. In contrast to chemotherapy (1), this new treatment does not kill tumor cells directly rather it enhances the sensitivity of the patient s own immune system against tumor cells with all the potential positive aspects like high selectivity of treatment and much less side effects (2). 

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