Lipooligosaccharides structures

Kim, J.J., Phillips, N.J., Gibson, B.W., Griffiss, J.M., Yamasaki, R. Meningococcal group A lipooligosaccharides (LOS) preliminary structural studies and characterization of serotype-associated and conserved LOS epitopes. Infect Immun 62 (1994) 1566-1575. 

Ierano, T., Siiipo, A., Sturiale, L., Garozzo, D., Bryant, C., Lanzetta, R., Parrilli, M., Aldridge, C., Gould, F.K., Corris, P.A., Khan, C.M., De Soyza, A., Molinaro, A. First structural characterization of Burkholderia vietnamiensis lipooligosaccharide from cystic fibrosis-associated lung transplantation strains. Glycobiology 19(11) (2009) 1214-1223. 

St. Michael, F., Li, J., Vinogradov, E., Larocque, S., Harper, M., Cox, A.D. Structural analysis of the lipooligosaccharide of Pasteurella multocida strain VP161 identification of both Kdo-P and Kdo-Kdo species in the lipopolysaccharide. Carbohydr Res 340 (2005b) 59-68. 

Vinogradov, E., Korenevsky, A., Beveridge, T.J. The structure of the rough-type lipooligosaccharide from Shewanella oneidensis MR-1, containing 8-amino-8-deoxy-Kdo and an open-chain form of 2-acetamido-2-deoxy-D-galactose. Carbohydr Res 338 (2003) 1991-1997. 

Fig. 2. Generalised structure of the dephosphorylated Haemophilus influenzae and ducreyi lipooligosaccharide without the lipid A part...

More recently, studies on Campylobacter jejuni have demonstrated how specific bacterial carbohydrate antigens can mimic the fine structure of human cell surface glycolipid structures and elicit autoimmune reactivity. Yuki et al.61 first identified that the lipooligosaccharide (LOS) of C. jejuni mimicked human G(M)1 ganglioside and subsequently extended these studies to demonstrate that specific single amino acid variants of the C. jejuni Cst-II sialyltransferase protein are responsible for the synthesis of LOS variants that in turn, mimic different... 

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