Lipid immunomodulators

Persing, D.H., Coler, R.N., Lacy, M.J., Johnson, D.A., Baldridge, J.R., Hershberg, R.M., Reed, S.G. Taking toll lipid A mimetics as adjuvants and immunomodulators. Trends Microbiol 10... 

Palfium dextromoramide. palmidrol [inn] is a lipid compound isolated from soyabean lecithin, egg yolk and peanut meal. It has IMMUNOMODULATOR and ANTliNFlAMMATORY properties, palonosetron [inn] (palonosetron hydrochloride [usan] RS 42358) is a benzisoquinolinone derivative, a selective (5-HT]) 5-hydroxytryptamine receptor antagonist, with ANTIEMETIC and anxiolytic activity, palonosetron hydrochloride palonosetron. PalUdrine proguanil. 

MPL (monophosphoryl lipid A) Although the effectiveness of LPS as an immunomodulator has long been known, the pharmacologic use of purified LPS (or lipid A) as an adjuvant is precluded by its toxicity. LPS is highly... 

Investigations on the actions of lipoxins in various cell types and in vivo, helped to establish these lipid mediators as immunomodulators that exhibit potent antiinflammatory and pro-resolving actions. In addition to reducing excessive and persistent inflammation, LXA4 and its synthetic stable analogs were the first molecules... 

FIGURE 37.11 Activity of CN, antioxidant and immunomodulant compounds on skin surface lipids of women affected by dry skin after 60 days of bi-daily treatment on facial skin. 

Reithmeier, H., Gopferich, A., and Herrmann, L, Preparation and characterization of lipid microparticles containing thymocartin, an immunomodulating peptide. Proceedings of the International Symposium on Controlled Release of Bioactive Materials,Yol. 26, p. 681,1999. 

The polyanions can function as chemical immunomodulators and produce a wide spectrum of effects on the immune system. It was reported that the polyanions have the capacity to activate macrophages, which may be related to their effects on the plasma membrane lipids, and to provide immuno-modulation through B-cell stimulation [8,9]. It was also observed that the antiviral, antibacterial, and antitumor activities of pyran copolymer may be mediated by the induction of interferon (IFN) production [10], macrophage activation [11], or stimulation of antibody-dependent cellular cytotoxicity... 

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