Linker for activation of T cells

The catalytic pi 10 subunit has four isoforms, all of which contain a kinase domain and a Ras interaction site. In addition, the a, (3, and y isoforms possess an interaction site for the p85 subunit. The class I enzymes can be further subdivided class IA enzymes interact through their SH2 domains with phosphotyrosines present on either protein tyrosine kinases or to docking proteins such as insulin-receptor substrates (IRSs GAB-1) or linkers for activation of T cells (LATs in the case of T cells). 

Paz PE, Wang S, Clarke H, Lu X, Stokoe D, Abo A 2001 Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. Biochem J 356 461—471 Priatel JJ, Teh SJ, Dower NA, Stone JC, Teh HS 2002 RasGRPl transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation. Immunity 17 617-627... 

Zhu M, Janssen E, Zhang W 2003 Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. Immunol 170 325—333... 

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