Linezolid Warfarin

Clinically important, potentially hazardous interactions with alcohol, antidepressants, aspirin, heparin, linezolid, lithium, NSAIDs, sibutramine, tramadol, warfarin... 

Linezolid had only minor effects on the pharmacokinetics and anticoagulant activity of single-dose warfarin, which were not considered to be clinically significant. 

Linezolid 600 mg twice daily was given to 13 healthy subjects for 5 days followed by a single 25-mg dose of warfarin. The pharmacokinetics of warfarin with linezolid were within 20% of those seen with warfarin alone, and the INR was minimally affected (about a 10% increase in maximal INR). These effects were not considered to be clinically relevant. See also antibacterials , (p.365). 

AzieNE, Stalker DJ, JungbluthGL, Sisson T, Adams G. Effect of linezolid on CYP2C9 using racemic warfarin (W) as a probe. Clin Pharmacol Ther (200 ) 69, 21. 

---