Linezolid Epinephrine

Drugs that may interact with linezolid include monoamine oxidase inhibitors, SSRIs, and adrenergic agents (eg, dopamine, epinephrine). 

Clinically important, potentially hazardous interactions with amprenavir, clonidine, ephedra, epinephrine, eucalyptus, guanethidine, iobenguane, isocarboxazid, linezolid, MAO inhibitors, paroxetine, phenelzine, quinolones, sparfloxacin, St John s wort, tranylcypromine... 

Because of its weak MAO-inhibitory properties, the manufacturers of linezolid contraindicate its use with sympathomimetics (such as adrenergic bronchodilators, phenylpropanolamine, pseudoephedrine, adrenaline (epinephrine), noradrenaline (norepinephrine), dopamine and dobutamine) unless facilities for close observation and blood pressure monitoring are available. In one study the use of linezolid with phenylpropanolamine or pseudoephedrine resulted in additive hypertensive effects. 

The manufaeturers eontraindieate the use of sympathomimetics (including adrenergic bronchodilators, pseudoephedrine, phenylpropanolamine, adrenaline (epinephrine), noradrenaline (norepinephrine), dopamine, dob-utamine) with linezolid unless there are faeilities available for close observation of the patient and monitoring of blood pressure. Some indirectly-aeting sympathomimetics occur in cough and cold remedies, whieh can be bought without prescription. To keep in line with the manufaeturers recommendations, patients should be told to avoid these preparations. However, it should be said that the evidenee available indicates that blood pressure rises are unlikely to be of the proportions seen with the antidepressant MAOIs, which result in hypertensive crises. Consider also MAOIs or RIMAs + Sympathomimetics Indirectly-acting , p.l 147. 

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See also in sourсe #XX -- [ ]

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