Linear molecular recognition

Hosseini, M. W., Lehn, J. M., Anion coreceptor molecules - linear molecular recognition in the selective binding of dicar-boxylate substrates by ditopic polyammonium macrocycles. Helv. Chlm. Acta 1986, 69, 587-603. 

Fages, F., Desvergne, J. P, Kampke, K., etal., Linear molecular recognition - spectroscopic, photophysical, and complexation studies on alpha,omega-alkanediyldiammonium ions binding to a bisanthracenyl macrotricyclic receptor. J. Am. Chem. Soc. 

Stable and highly selective complexes with organic dicarboxylate anions, 02C-(CH2)m-C02. These macrocycles display linear molecular recognition based on ditopic binding between two triammonium units of the macrocycle and the two terminal C02 groups of the dicarboxylate anion. The most stable... 

Selectivity studies of these ligands towards H3N(CH2) NH3 (n = 2-9) substrates reveal (92,93) that the substrate preferentially bound has a length complementary to the length of the molecular host cavity (linear molecular recognition) (Table 2.7). 

These results provide a basis for structural receptor-substrate complementarity in linear molecular recognition. 

Dramatic examples have also been reported for main-chain supramolecular polymers (SPs Lehn 1993 Ciferri 2005 Fig. 3.1), in which specific and directional molecular recognition events between end groups define the main chain of a linear polymeric assembly. Although main-chain SPs had been created and characterized previously (Broze et al. 1983 Fouquey et al. 1990 Alexander et al. 1993 Bladon and Griffin 1993 St Pourcain and Griffin 1995), it was a groundbreaking paper in 1997 that demonstrated the mechanical potential of supramolecular interactions and catalyzed much of the current interest in the field (Sijbesma et al. 1997). 

Self-Organization of Supramolecular Liquid Crystalline Polymers from Complementary Components. If two (or more) complementary units e or 3 are grafted on a template T, mixing Te m with the complementary T3m may lead to the hetero-self-assembly of a linear or cross-linked, main-chain supramolecular copolymer species (Te m, Tsw), whose existence is conditioned by the molecular recognition-directed association between the e and a groups. 

Ermer, O., Eling, A., Molecular recognition among alcohols and amines - super-tetrahedral crystal architectures of linear diphenol-diamine complexes and aminophenolse. J. Chem. Soc., Perkin Trans. 21994, 925-944. 

Lehn, J. M. Sonveaux, E. Willard, A. K. Molecular recognition. Anion cryptates of a macrobicyclic receptor molecule for linear triatomic species, J. Am. Chem. Soc. 1978,100, 4914-4916. 

Among the different types of compounds whose complexation properties have been studied are various amides linear oxoamide 9 [22], fumaramide 10 [23,24] and methanetricarboxamide 11 [25], biphenyl derivatives 12 [26], and derivatives of tartaric acid 13-16, that can also be prepared in an optically active form [27], The above-mentioned chiral hosts have been found to form inclusion complexes with chiral guests 17 and 18. Molecular recognition between chiral hosts and... 

For the synthetic chemist [14], the synthetic behavior of an assembler is akin to a molecule that functions as a template (Figure 2) [13], The pick-and-place paradigm evoked by an assembler [1] suggests a molecule that grabs and positions two molecules for a reaction that leads to a covalent bond. Moreover, such structure behavior is reminiscent of a linear template, a ditopic molecule that juxtaposes, by way of molecular recognition and self-assembly [5], two molecules linearly to achieve a particular linking of atoms. 

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