Linear ion trap tandem

Farre M, Perez S, Gajda-Schrantz K, Osorio V, Kantiani L, Ginebreda A, Barcelo D (2010) First determination of C60 and C70 fullerenes and N-methylfulleropyrrolidine C60 on the suspended material of wastewater effluents by liquid chromatography hybrid quadrupole linear ion trap tandem mass spectrometry. J Hydrol 383(l-2) 44-51... 

QqLIT-MS-MS Quadrupole linear ion trap tandem mass spectrometer... 

In the triple quadrupole linear ion trap, tandem MS is performed in space where the LIT serves only as a trapping and mass-analyzing device. Figure 1.25 illustrates the difference between quadrupole CID spectra and trap CID spectra for trocade. 

Sauvage FL, Saint-Marcoux F, Duretz B, Deporte D, Lachatre G, Marquet P (2006) Screening of drugs and toxic compounds with liquid chromatography-linear ion trap tandem mass spectrometry. Clin Chem 52 1735-1742... 

An LTQ linear ion trap tandem mass spectrometer (Thermo Finnigan Corp, San Jose, CA) is routinely used in our laboratory. XCalibur Software is used to automate the acquisition of tandem mass spectra over a 400-1600-m/z range and to control precursor ion selection by the instrument in a data-dependent, data-acquisition mode, with dynamic exclusion activated. 

Reich RF, Cudzilo K, Yost RA. Quantitative imaging of cocaine and its metabolites in postmortem brain tissue by intermediate-pressure MALDI/linear ion trap tandem mass spectrometry. Paper presented at the 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, 2008. 

In terms of mass spectrometric analyzers, TAG analysis has been developed and implemented successfully with tandem quadrupoles and linear ion traps tandem mass spectrometry (MS/MS) techniques allowr unambiguous structural characterization of mixtures of isobaric species. 

The TOF mass analyzer has a low duty cycle, and the combination with an ion accumulation device such as an ion trap is therefore very advantageous. It offers also MS capabilities with accurate mass measurement. In all acquisition modes, the ions are accelerated into the time of flight for mass analysis. Various other hybrid mass spectrometers with TOF have been described, including quadrupole ion trap [70] and linear ion trap [58]. High energy tandem mass spectrometry can be performed on TOF-TOF mass spectrometers [71, 72]. 

Hager, J. W. (2003). Product ion spectral simplification using time-delayed fragment ion capture with tandem linear ion traps. Rapid Commun. Mass Spectrom. 17 1389-1398. 

Hager, J. W., and Le Blanc, J. C. (2003). High-performance liquid chromatography-tandem mass spectrometry with a new quadrupole/linear ion trap instrument. J. Chromatogr. A 1020 3-9. 

Vallverdu-Queralt, A. Jauregui, O. Medina-Remon, A. Andres-Lacueva, C. Lamuela-Raventos, R.M. 2010. Improved characterization of tomato polyphenols using liquid chromatography/electrospray ionization linear ion trap quadrupole Orbitrap mass spectrometry and liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Comm. Mass Spectrom. 24 2986-2992. 

A third type of MS/MS instruments is a hybrid of tandem-in-space and tandem-in-time devices, including the Q-trap (QQ-2D-linear trap) [45] and the ion trap-FT-ICR (2D-linear ion trap-FT-ICR) [46]. The Q-trap takes the configuration of triple quadrupole, with the third quadrupole replaced by a 2D-linear ion trap. The uniqueness of this design is that the 2D-linear ion trap component can be used to perform either (a) a normal quadrupole scan function in the RF/DC mode or (b) a trap scan function by applying the RF potential to the quadrupole. It is well-suited for both qualitative and quantitative studies. In the case of ion Trap-FT-ICR, it combines ion accumulation and MS" features of a 2D-linear ion trap with excellent mass analysis capability (mass resolution, mass accuracy, and sensitivity) of FT-ICR. 

The methods for each study are divided into the initial protein separation step, a second separation step if applicable, the type of mass analysis, and the software used for peptide identification. ID = one dimensional polyacrylamide gel electrophoresis, 2D = two dimensional polyacrylamide gel electrophoresis, MS = mass spectrometry (peptide mass fingerprinting), MS/MS = tandem mass spectrometry, MALDI-TOF = matrix assisted laser desorption/ionization-time of flight, MS FIT = software from Protein Prospector, http //prospector.ucsf edu/, ESI = electrospray ionization, Q-TOF = quadrupole-time of flight, PPSS2 =Protana s Proteomic Software Suite (ProtanaEngineering, Odense, Denmark), Mascot = Matiix Science, http //www.matrixscience.com/, TOF-TOF = MALDI plus TOF tandem mass spectrometry, RP-HPLC = reverse phase high performance liquid chromatography, Q-IT = quadrupole ion trap, LIT = linear ion trap. Bioworks = Thermo Electron Corporation. 

Linear Ion Trap (2D)/Hybrid Tandem Mass Spectrometry... 

Campbell, J.M., Collins, B.A., and Douglas, DJ. (1998). A Linear Ion Trap Time-of-flight System with Tandem Mass Spectrometry Capabilities, Rapid Commun. Mass Spectrom., 12,1463-1474. 

Tandem methods for chemical measurements are now widely accepted and employed even when tandem is defined in the narrowest sense, such as two-dimensional gas chromatography or tandem mass spectrometry. Tandem or triple quadrupole MSs became commercially available in the early 1980s, and today these instruments are routine concepts as linear quadrupole analyzers or as ion traps. Tandem or sequential methods result in loss of signal current, yet noise is lost more so thus, S/N is increased. 

Campbell, J.M. Collings, B.A. Douglas, D.J. A new linear ion trap time-of-fiight system with tandem mass spectrometry capabilities. Rapid Commun. Mass Spectrom. 1998, 12, 1463-1474. 

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