Lindera umbellata

Very recently, the method has been used for the synthesis of racemic linderol A [311], a natural product isolated from the fresh bark of Lindera umbellata. This compound is reported to exhibit potent inhibitory activity on the melanin biosynthesis of cultured B-16 melanoma cells in guinea pigs, without causing any cytotoxicity in the cultured cell or skin irritation [312]. 

Mimaki, Y. et ah, A novel hexahydrodibenzofuran derivative with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells from Lindera umbellata bark, Chem. Pharm. Bull, 43, 893, 1995. 

Ichino, K., Tanaka, H., and Ito, K., Isolation and structure of 2 new flavonoids from Lindera umbellata, Chem. Lett., 363, 1989. 

Ichino, K., Two flavonoids from two Lindera umbellata varieties. Phytochemistry, 28, 955, 1989. 

A crude extract of Linderae umbellatae exhibited antipeptic and antiulcerogenic activity, and these effects were considered ascribable to the presence of tannins or related compounds. Nine condensed tannins (monomers, dimers, trimers, and tetramers) have been isolated and their antipeptic and antiulcer activity confirmed experimentally (pylorus ligated in rats and stress-induced gastric lesions in mice). 

Morimoto S, Nonaka G, Nishioka I, Ezaki N, Takizawa N 1985 Tannins and related substances. 29. Seven new methyl-derivatives of flavan-3-ols and l,3-diaryl-propan-2-ol from Cinnamomum cassia, C. obtusifolium and Lindera umbellata van membranacea, Chem Pharm Bull 33 2281-2286... 

Hernandia peltata Lindera umbellata Liquidambar orientalis Magnolia kobus Ocotea pretiosa Octomeles sumatrana Populus spp. 

Ezaki N, Kato M, Takizawa N, Morimoto S, Nonaka G, Nishioka I 1985 Pharmacological studies on Linderae umbellatae Ramus. IV. Effects of condensed tannin related compounds on peptic activity and stress-induced gastric lesions in mice. Planta Med 34-38... 

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