Lindane channel

Cyclodiene pesticides, of which endrin and its oxidized analogs are representative, can also be estimated by receptor-assay technique. Cyclodiene pesticides exert their mode of action by altering central nervous system membrane ion transport. In work reported by Saleh et al. (1993), a labeled amino acid, GABA, that binds to the chloride channel receptor is displaced by endrin (and other similar molecules), and thus serves as an assay for these pesticides. The GABA receptor was shown to be a potentially useful biomarker for organochlorine pesticides such as lindane, toxaphene, endrin, chlordane, and others. The assay involves small quantities of blood (0.1 mL), and requires only that the plasma be separated from the... 

GABA-gated chloride channels Cyclodienes, lindane, phenylpyrazoles, Avermectins, emamectin benzoate, milbemectin Antagonism Chloride channel activators... 

The toxicity of lindane is related to the blocking of the Cl- channels and interference with the GABA receptors in the nervous system, including the brain, giving rise to sublethal effects and death at higher levels of exposure (Eldefrawi and Eldefrawi, 1990 Walker et al., 2001). 

Action of Cyclodienes and Lindane on a Voltage-dependent Chloride Channel... 

Avermectin Bia (AVM) acts on both GABA-operated and voltage-dependent chloride channels, but its action on both is quite different from those of cyclodienes, lindane or pyrethroids. In rat brain preparations, AVM induces 36C1" influx which is inhibited by the... 

Lindane effectively blocks one of the components of the GABA-activated chloride channel current, and this action appears to be responsible for synaptic hyperactivity. 

One important group of insecticides, the avermectins, works differently by being agonists and not antagonists as the other, acting on the chloride channels. The avermectins are produced by Streptomyces avermitilies. The binding site is different, and cross-resistance to fipronil, the cyclodienes, and lindane does not seem to occur. The toxic symptoms in insects and mammals are different. Mammals poisoned with avermectins exhibit hyperexcitability, incoordination, and tremor followed by ataxia and paralysis. In insects and nematodes, the hyperexcitation phase is absent. Their symptoms are... 

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