Limitations, unnecessary

In application of the Newton-Raphson iteration to these objective functions [Equations (7-23) through (7-26)], the near linear nature of the functions makes the use of step-limiting unnecessary. 

Setting up of a European database for all member states with clinical trial information (to limit unnecessary trials)... 

We have seen that it is dangerous to oversize the valve the ability to adjust flow both compensates for this and limits unnecessary product loss (Figure 5.41). 

For consolidation, however, UXO must be moved to the disposal site and possibly stored until enough UXO is amassed for an efficient disposal detonation. For large disposal detonation, the disposal site is chosen, rather than being dictated by where the UXO was found, as in BIP. Previously disturbed sites can be selected for the UXO disposal area, thereby limiting unnecessary additional environmental impact to other areas. The environmental impacts are contained in the selected area, which can be completely remediated after UXO disposal operations. 

When the exposure is well below the limit values and it is possible to be confident that on a long-term basis the probability of exceeding the limit value is very low, the risk assessment may conclude that the nature and extent of the risks related to those chemical agents make a further detailed risk assessment unnecessary unless work conditions are modified in a significant way. In these cases, however, it must be regularly checked w hether the assessment leading to that conclusion is still applicable. 

Immunosera, which were once very widely used in the prophylaxis and treatment of many infections, are little used today, as vaccines have made some immunosera unnecessary and lack of proven therapeutic benefit has caused others to be relegated to immunological history. Tetanus antitoxin is an exception in that it is a very effective prophylactic that is still used in countries where there are inadequate supplies of tetanus immunoglobulin. Human immunoglobulins have important but limited uses. 

Nevertheless, multiple challenges persist. Reimbursement on a fee-for-service or contractual basis between institutions may not be feasible for the community hospital. Government reimbursement for telemedicine services may remain limited by interstate commerce restrictions and local practice requirements, and may depend on studies demonstrating that the costs of consultation are counterbalanced by avoiding unnecessary transfers. Additionally, privacy concerns must be properly addressed with secure, encrypted transfer of information and rules governing who may access the patient s medical information from a distance. 

The treatment staff must be aware of countertransference issues, and anticipate relapses and failures. For both patient and staff, it helps to define and accept limited goals. Appropriate security measures are necessary, so that staff can feel safe also, staff need to be educated about not taking unnecessary risks in handling these patients. Staff frustration has to be recognized and managed. 

Fluid restriction is generally unnecessary as long as sodium intake is controlled. The thirst mechanism remains intact in CKD to maintain total body water and plasma osmolality near normal levels. Fluid intake should be maintained at the rate of urine output to replace urine losses, usually fixed at approximately 2 L/day as urine concentrating ability is lost. Significant increases in free water intake orally or intravenously can precipitate volume overload and hyponatremia. Patients with stage 5 CKD require renal replacement therapy to maintain normal volume status. Fluid intake is often limited in patients receiving hemodialysis to prevent fluid overload between dialysis sessions. 

In practice, the choice of parameters to be refined in the structural models requires a delicate balance between the risk of overfitting and the imposition of unnecessary bias from a rigidly constrained model. When the amount of experimental data is limited, and the model too flexible, high correlations between parameters arise during the least-squares fit, as is often the case with monopole populations and atomic displacement parameters [6], or with exponents for the various radial deformation functions [7]. 

Calcium-sodium-chloride-type brines (which typically occur in deep-well-injection zones) require sophisticated electrolyte models to calculate their thermodynamic properties. Many parameters for characterizing the partial molal properties of the dissolved constituents in such brines have not been determined. (Molality is a measure of the relative number of solute and solvent particles in a solution and is expressed as the number of gram-molecular weights of solute in 1000 g of solvent.) Precise modeling is limited to relatively low salinities (where many parameters are unnecessary) or to chemically simple systems operating near 25°C. 

Here there is no limitation, as some scientists consider one to be unnecessary. The order of the definitions is not arranged with respect to their quality. 

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