Ligands with electrophiles

Stabilisation of Anions and the Reactions of Co-ordinated Ligands with Electrophiles... 

Whereas co-ordination to a metal is seen to have relatively little effect upon the reactivity of aromatic ligands with electrophiles, this is not the case in reactions with nucleophiles. In the same way that we might expect co-ordination to a metal ion to reduce the tendency for attack of an aromatic ring by electrophiles, we might expect the attack of nucleophiles to be enhanced. The majority of studies in this area have been concerned with the dramatic effects that copper salts have on the reactivity of aromatic ligands. Copper salts are... 

Several other examples of conversion of the cyclooctatetraene ligand with electrophiles have been reported. Here, however, other transformations were observed (see Sections 5.2.6.1.2.1.5. and 5.2.6.I.2.2.4.). 

Electrophilic attack on coordinated cyclopentadienyl rings, particularly those in ferrocene, is well established. This process occurs in a similar fashion to electrophilic attack on arenes and was used to establish the binding mode of the Cp ligand in ferrocene (see Equation 3.88). These reactions of the Cp ligand with electrophiles are described in more detail in Chapter 12, which covers electrophilic attack on coordinated ligands. Friedel-Crafts acylation, formylation, aminomethylation, and mercuration are all known. - ... 

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