Ligands glycine chelates

Figure 10.1 Chelation of Cu2+ by glycinate anion ligands to form the glycinate chelate. Each electron donor group on the glycinate anion chelating agents is designated with an asterisk. In the chelate, the central copper(ll) metal ion is bonded in four places and the chelate has two rings composed of the five-atom sequence Cu-O-C-C-N.

Based on our surface spectroscopic results, a bidentate mode of coordination of Ca " and Tb " with the carboxylate group of Fc-peptide acid cystamine films is proposed (Scheme 6.6). There is precedence for bidentate metal coordination to surface-bound ligands. In a study of lanthanide selective sorbents, Fryxell and coworkers showed that self-assembly of glycinate monolayers on mesopo-rous materials bound Eu " in an 8-coordinated fashion. In this system, the close proximity of the ligands allowed four bidentate ligands to chelate the lanthanide cation [73]. 

The strong chelating ability of (multi)amino(multi)carboxylate ligands renders complexes of bismuth substantially more hydrolytically stable than those of bifunctional aminocarboxylate ligands (e.g., glycine). Several compounds have been successfully examined as ligands for bismuth, in that complexes are readily isolable as molecular systems with weak intermolecular interactions. The extent and diversity of these complexes is enhanced by substituent derivatization with, for example, cyclohexyl (e.g., cydtpa) and alkoxyethyl (e.g., oedta) groups. 

Fig. 11. The slowly hydrolyzed substrate glycyl-L-tyrosine binds to carboxypeptidase A in a nonproductive complex where the amino-terminal glycine complexes the active-site ion (large sphere) to form a five-membered chelate, as in Fig. 10. Protein-bound zinc ligands Glu-72, His-69, and His-196 complete the coordinadon polyhedron of pentacoordinate zinc. Active-site residues are indicated by one-letter abbreviadons and sequence numbers E, glutamate H, hisddine R, arginine Y, tyrosine. [Reprinted with permission from Christianson, D. W., Lipscomb, W. N. (1986) Proc. Natl. Acad. Sci. U.S.A. 83,7568-7572.]...

On the other hand, Eichhorn (27, 57) has shown that the Schilf base of salicylaldehyde with glycine is stabilized by chelate formation at pH values where the free ligand is readily hydrolyzed. 

A similar reaction is observed with the Cu+2 complex. No reaction occurs with glycine esters. A similar reaction occurs when cobalt (III) complexes are prepared from solutions of hydroxyethylethylenediamine and similar ligands (24, 25). The chelate ring-forming portion of the complex remains intact however, the products derived from the oxidized hydroxyethyl group appear complicated. 

Not mentioned in Table 2 (and often not in the original papers ) is the optical form (chirality) of the amino acids used. All the amino acids, except for glycine (R = H), contain an asymmetric carbon atom (the C atom). In the majority of cases the optical form used, whether l, d or racemic dl, makes little difference to the stability constants, but there are some notable exceptions (vide infra). Examination of the data in Table 2 reveals (i) that the order of stability constants for the divalent transition metal ions follows the Irving-Williams series (ii) that for the divalent transition metal ions, with excess amino acid present at neutral pH, the predominant spedes is the neutral chelated M(aa)2 complex (iii) that the species formed reflect the stereochemical preferences of the metal ions, e.g. for Cu 1 a 2 1 complex readily forms but not a 3 1 ligand metal complex (see Volume 5, Chapter 53). Confirmation of the species proposed from analysis of potentiometric data and information on the mode of bonding in solution has involved the use of an impressive array of spectroscopic techniques, e.g. UV/visible, IR, ESR, NMR, CD and MCD (magnetic circular dichroism). 

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