Ligands bioprobes

The novel /V-hcicrocyclic carbene (NHC) l,3-dicyclohexyl-l,3-diazepan-2-ylidene 80 and its 5,6-dioxolane derivative 81 were synthesised and their coordination chemistry with Rh(I), Ir(I), and Pt(0) explored. The coordinated carbene ligands display extremely large NCN bond angles in crystal structures <0704800>. The cyclic urea 82 was synthesised and fluorescent properties studied in a search for new DNA/RNA bioprobes <07JOC102>. 

In principle, catalytic antibodies can be developed to facilitate selective chemical reactions that do not have biological counterparts (Benkovic et al. 1988). For example, toxins could be selectively detoxicated, novel chemical reactions could be developed, or extremely sensitive bioprobes of antibody ligands could be readily developed. 

Elhabiri et al., 2004a). The ultimate fixation of the third ligand in the neutral helicate [f 2(L13%] induces a considerable entropic gain to the overall complexation process, which is responsible for both extreme thermodynamic stability (Elhabiri et al., 1999) and kinetic inertness (Elhabiri et al., 2004b, Figure 59), which make these helicates promising building blocks for the development of luminescent bioprobes (see Section 6). 

It can be seen from this discussion that the IR based read-out of information from organometallic bioprobes with carbonyl ligands by analysis of the vibrational band envelopes viewed through the window of the water background spectrum has a number of imusual features. The v(CO) signals are intense and narrow, can... 

Ligands Near-Infrared Materials Lanthanides Magnetic Resonance Imaging Luminescent Bioprobes Sensors for Lanthanides and Actinides. 

Some examples are emphasized in the next chapter Lanthanides Luminescence Applications). The luminescence spectra of various lanthanide ions will be given and several applications using luminescent lanthanide complexes will be presented. Luminescent Bioprobes, some practical data and a case of study will be presented. The properties of a series of lanthanide complexes (i.e., with ligands that share a common architectme) will be expUcated both from a physicochemical and from a photophysical point of view. It will be demonstrated that these complexes are highly stable and present interesting photophysical properties, so that their application as bioprobe can be imdertaken. 

Carboxylate Lanthanide Complexes with Multi-dentate Ligands Lanthanides Luminescence Applications Lanthanides in Living Systems Luminescence Luminescent Bioprobes Metal-Organic Frameworks Molecular Magnetic Materials Near-Infrared Materials. 

Scheme 4.5 Polyaminocarboxylate ligands and Eu", Tb " complexes for molecular bioprobes...

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