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Ligand-based focused design

This chapter focuses on computational studies which employ a combination of structure-based and 3D QSAR methods as a mean to predict the affinity of a ligand for its receptor. The comprehensive utility of this approach is exemplified by case studies published in the last few years and from our laboratory. Special emphasis will be placed on a detailed description of the combined structure-ligand-based approach and the successful application of this procedure to the design of novel drug molecules. [Pg.225]

Ligand-based Design of Focused Compound Libraries... [Pg.341]

See other pages where Ligand-based focused design is mentioned: [Pg.19]    [Pg.19]    [Pg.347]    [Pg.193]    [Pg.341]    [Pg.278]    [Pg.32]    [Pg.6]    [Pg.445]    [Pg.182]    [Pg.184]    [Pg.339]    [Pg.342]    [Pg.58]    [Pg.16]    [Pg.113]    [Pg.367]    [Pg.368]    [Pg.526]    [Pg.592]    [Pg.601]    [Pg.605]    [Pg.614]    [Pg.221]    [Pg.348]    [Pg.279]    [Pg.342]    [Pg.371]   
See also in sourсe #XX -- [ Pg.16 ]



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Design Bases

Design ligand-based

Focused design

Ligand design

Ligand-based

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