Lewis type-1 blood-group antigens

The expression of type-1 Lewis blood-group antigens suggests that for the biosynthesis of some H. pylori LPS molecules there must be glycosyltransferases... 

M.A. Monteiro, K.H. Chan, D.A. Rasko, D.E. Taylor, P.Y. Zheng, B.J. Appelmelk et ai. Simultaneous expression of type 1 and type 2 Lewis blood group antigens by Helicobacter pylori lipopolysaccharides. Molecular mimicry between H. pylori Upopolysaccharides and human gastric epithelial cell surface glycoforms, J. Biol. Chem., 1998,273, 11533-11543. 

H. pylori P466 was also shown to have the ability to elaborate the cancer-associated sialyl Le antigen in its LPS. The sialyl Le was expressed simultaneously with Le and, in lesser amounts, the Le antigen. These Lewis blood-group termini were connected to the a core OS similar to that of the type strain. 

Lewis Y antigen BC8-F3 Difucosylated tetrasaccharide found on type 2 blood group oligosaccharide SK-LU-3 lung cancer cell line Signet 1 40 HIER... 

The structures of three new disialylfucosyl hexasaccharides, two new nona-saccharides, and a pentasaccharide isolated from human milk have been elucidated. The structures indicate that, in contrast to those of the ABO and Lewis blood-groups, the H determinant is located only on the type-I carbohydrate chain of the branched moiety. Extraction of bovine milk-fat globule membranes with phenol afforded three glycoproteins, which released the T antigen on treatment with alkaline borohydride and desialylation. ... 

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