Leukocyte function-associated

Inamura, N., Mekori, Y.A., Bhattacharyya, S.P., Bianchine, P.J. and Metcalfe, D.D. (1998) Induction and enhancement of FcERI-dependent mast cell degranulation following coculture with activated T cells dependency on ICAM-1- and leukocyte function-associated antigen (LFA)-l-mediated heterotypic aggregation. Journal of Immunology 160, 4026-4033. 

Selected adhesion molecules represent yet another antibody target. Adhesion molecules, such as LFA-1 (leukocyte function-associated antigen-1) and ICAM-1 (intercellular adhesion molecule 1), play central roles in promoting migration of inflammatory cells to the sites of damage. Such activities underlie many of the symptoms of conditions such as rheumatoid arthritis. Inhibition of adhesion molecule function by administration of antibodies raised against them may, therefore, demonstrate therapeutic potential in some instances. 

LFA Leukocyte function-associated antigen MAB Monoclonal antibody MHC Major histocompatibility complex NK cell Natural killer cell... 

The ability of NOE matching to identify the correct pose from a collection of decoy poses was demonstrated on three test cases involving lead-like compounds bound to small proteins. One of these test cases involves muscle fatty acid-binding protein (mFABP) and the other two involve the leukocyte function-associated antigen 11-domain (LFA-1). As these results have been presented in detail elsewhere,1151 here we only summarize the results obtained when the BMRB average chemical shifts (diamagnetic protein statistics) were used for chemical shift predictions. The compounds used for these test cases are shown in Scheme 5.1 (compound 3 contains a proprietary core, which is represented by an ellipse). 

Liu G, Huth JR, Olejniczak ET, Herdoza R, DeVries P, Lietza S, Reilly EB, Okosinski GF, Fesik SW, vonGeldern TW, Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-l/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties, J. Med. Chem., 44 1202-1210, 2001. 

Hayashi et al. (1996) tested the effects of a flavonoid in original-type anti-glomerular basement membrane antibody associated glomerulonephritis in male Sprague Dawley rats on upregulation of intracellular adhesion molecule expression and on increase in leukocyte function-associated antigen positive cells in nephritic glomeruli. 

Potin D, Launay M, Monatlik F et al (2006) Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-l-methyl-2,4-dioxo-l,3,7-triazaspiro[4.4]non-7-ylmethyl]-3-thiophenecarboxylic acid (BMS-587101) - a small-molecule antagonist of leukocyte function associated antigen-1. J Med Chem 49 6946-6949... 

Dallegri F, Ottonello L, Ballestrero A, Dapino P, Ferrando F, Patrone F, Sacchetti C Tumor cell lysis by activated human neutrophils Analysis of neutrophil-delivered oxidative attack and role of leukocyte function-associated antigen 1. Inflammation 1991 15 15-30. 

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