Leukocyte differentiation antigens

Lanier LL, Testi R, Bindl J, et al. Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule.Med. 1989 169 2233-2238. 

CD acronym of cluster differentiation or cluster designation a system of nomenclature for human leukocyte differentiation antigens recognized by mon-clonal antibodies Also the acronym of Circular di-chroism (see). 

C23. Cobbold, S., Hale, G., and Waldmann, H., Non-lineage, LFA-1 family, and leucocyte common antigens New and previously defined clusters. In Leukocyte Typing III White Cell Differentiation Antigens (A. J. McMichael, P. C. L. Beverley, S. Cobbolds, etal., eds.), pp. 788-804. Oxford University Press, Oxford, 1987. 

Zl. Zhou, L.-J., and Tedder, T. F., CD20 workshop panel report. In Leukocyte Typing V White Cell Differentiation Antigens (S. F. Schlossman, L. Boumsell, W. R. Gilks, et al. eds.), pp. 511-514. Oxford University Press, New York, 1995. 

An abbreviated panel of antibodies directed against three antigens— keratin, S-100 protein, and CD45 (Leukocyte Common Antigen-LCA)— can separate poorly differentiated tumors into four diagnostic categories carcinoma, neural tissue tumor/melanoma, hematopoietic tumor, and sarcoma as shown in Table 2. 

Non-Hodgkin lymphoma is sometimes part of the differential in poorly differentiated large cell malignancies. Most forms of lymphoma can be ruled in or out by the use of antibodies to CD45RB (leukocyte common antigen), S-100, and cytokeratin (e.g., the AE1/AE3 mixture or CAM5.2). Pitfalls to avoid pertain particularly to anaplastic large cell lymphoma (ALCL), which may... 

Key PMN, polymorphonuclear leukocytes EC, endothelial cell lymphs, lymphocytes CD, cluster of differentiation iCAM, intercellular adhesion molecule LFA-1, lymphocyte function-associated antigen-1 PECAM-1, platelet endothelial cell adhesion cell molecule-1. 

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