Leukemia lineage

In order to evaluate the in vitro antitumor activity of the prodrugs, compounds 20 and 21 were incubated at varied concentrations with human T-lineage acute lymphoblastic leukemia MOLT-3 cells in the presence or absence of ImM of PGA. The data from the cell proliferation assays are presented in Fig. 5.15. 

Immunophenotyping by flow cytometry has taken on an increasingly important role in the diagnosis of leukemia. Owing to the ease of application, sensitivity, and quantifiable results, flow cytometry is the preferred method for lineage assignment.7 This approach takes advantage of the development of monoclonal antibodies... 

Uckun FM, Sensei MG, Sun L et al. Biology and treatment of childhood T-lineage acute lymphoblastic leukemia. Blood 1998 91 735-746. 

Moreover gene-expression analysis of leukemia cells from B-lineage acute lymphoblastic leukemia pediatric patients has identified sets of differentially expressed genes that are associated specifically with sensitivity or resistance to chemotherapy. Such information can also be used in diagnostic assay to stratify the patients in sub-categories, to develop new drugs and later on to personalize the anti-cancer therapy. 

Lymphoblastic leukemia has been described after treatment of a malignant germ cell tumor it was suggested that this was related to the etoposide component of the treatment, and that development of secondary leukemia after etoposide may not be confined to the myeloid cell lineage (82). 

The lymphomas are neoplasms of B-, T- or natural killer cells, and characteristically present as tumorous enlargements of peripheral lymphoid or extranodal tissues. As with the leukemias, the lymphomas are subclassified into distinct clinicopathological entities based on lineage, cell of origin and/or putative normal counterpart, and degree of differen-... 

The chronic myeloid leukemias are characterized by translocations that lead to constitutive activation of tyrosine kinases. As mentioned earlier, the most common of these is the t(9 22)(q34 qll), resulting in the BCR/ABL fusion that is characteristic of CML. Up to seven different chromosomal translocations are associated with the chronic leukemias of myeloid/monocytic lineage, but all are charac-... 

Wasserman R, Galih N, Ito Y, Shber JH, Reichard BA, Shane S, et al. Residual disease at the end of induction therapy as a predictor of relapse during therapy in childhood B-lineage acute lymphoblastic leukemia. J Clin Oncol 1992 10 1879-88. 

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