Leucine-rich repeat proteins

Signaling by PKC is terminated by concentrations of its ligands dropping to basal levels (i.e., Ca2+ and diacylglycerol) and by dephosphorylation of the three processing sites. Dephosphorylation is controlled, in part, by a recently discovered hydrophobic phosphorylation motif phosphatase. This phosphatase, PHLPP (for PH domain Leucine-rich repeat Protein Phosphatase) dephosphorylates conventional and novel PKC isozymes, initiating their downregulation. 

The von Willebrand factor (vWf) is a heterogeneous multimeric plasma glycoprotein produced by megakaryocytes and endothelial cells which is found in platelets, plasma and the subendothelium. Subendothelial vWf facilitates platelet adhesion, especially under high shear stress, by binding to glycoprotein GPIb-V-IX, a complex of four leucine-rich repeat proteins on platelets. 

Li, Z.H., Molecular cloning and characterization of phytoene desaturase cDNA and leucine-rich repeat protein kinase cDNA from maize, PhD dissertation. Graduate School and University Center, City University of New York, 1998. 

Evdokimov, A. G., Anderson, D. E., Routzahn, K. M., and Waugh, D. S. (2001). Unusual molecular architecture of the Yersinia pestis cytotoxin YopM A leucine-rich repeat protein with the shortest repeating unit./. Mol. Biol. 312, 807-821. 

Kajava, A. V. (1998). Structural diversity of leucine-rich repeat proteins. J. Mol. Biol. 277,... 

II.2f Phlpp +103 kb (il) R 1E2.1 0 PH domain and leucin rich repeat protein phosphatase, dephos phorylates Akt, promotes apoptosis, and snppresses tnmonr growth 2... 

The R proteins, which act as receptors for Avr, and other elicitor proteins, are usually leucine-rich-repeat proteins with a characteristic nucleotide binding site attached (NB-LRR proteins).534,537 Like other cell surface receptors they participate in signaling and utilize both ion channels and Ser/Thr protein kinases.538 The Arabidopsis genome contains 150 sequences that may represent NB-LRR receptors.530... 

Guyon V, Tang W-H, Monti MM, Raiola A, Lorenzo G, McCormick S, Taylor LP. 2004. Antisense phenotypes reveal a role for SHY, a pollen-specific leucine-rich repeat protein, in pollen tube growth. Plant J 39 643-654. 

A. The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. J Biol Chem 2002 277 15061-15068. 

Figure 1 Dendrogram to illustrate the relationships between the different small leucine-rich repeat proteins/proteoglycans (SLRPs). SLRPs belonging to Classes I and II have 12 leucine-rich repeats while those in Class III have 7. The spacing of N-terminal cysteines differs in each class. ECM2 is considered to be Class I related, while nyctalopin and chondroadherin each have distinct sequence and structural characteristics.

McEwan PA, Scott PG, Bishop PN, Bella J. Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans. J Struct Biol 2006 155 294-305. 

Onnerfjord P, Heathfield TF, Heinegard D. Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. J Biol Chem 2004 279 26-33. 

Majava M, Bishop PN, Hagg P, Scott PG, Rice A, Inglehearn C, Hammond CJ, Spector TD, Ala-Kokko L, Mannikko M. Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia. Hum Mutat 2007 28 336-344. 

PHLPP pleckstrin homology PH-domain leucine-rich repeat protein phosphatase Bradley EW et al J Biol Chem 2013 288 9572-9582. 

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