Leucine-rich repeat kinase 2 gene

PD is generally a sporadic disorder, but in a significant proportion of cases (10-15% in most studies) it runs in families without a clearcut Mendelian pattern. Currently, there have been 13 defined loci identified as associated with high-penetrant autosomal dominant or recessive PD, of which causative mutations in specific genes have been identified. These genes include a-synuclein, parkin, ubiquitin carboxyl-terminal esterase LI (UCH-Ll), PTEN-induced putative kinase 1 (PlNKl), DJ-1, and leucine-rich repeat kinase 2 (LRRK2). As outlined in Table 3, most of these mutations can be characterized by an early onset of disease. 

The gene FLORAL ORGAN NUMBER1 regulates floral meristem size in rice and encodes a leucine-rich repeat receptor kinase orthologous to Arabidopsis CLAVATA1. Development, 131,5649-5657. 

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